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BCR — ZAP70
Text-mined interactions from Literome
Chen et al., Blood 2002
(Diseases in Twins...) :
Following BCR ligation, ZAP-70 underwent tyrosine phosphorylation and became associated with surface immunoglobulin and CD79b, arguing for the
involvement of
ZAP-70 in
BCR signaling
Gobessi et al., Blood 2007
(Leukemia, B-Cell...) :
We show that
BCR mediated activation of
ZAP-70 is very inefficient in CLL and lymphoma B cells and is negligible when compared to activation of Syk ... We conclude that the
role of
ZAP-70 in
BCR signaling is quite distinct from its role in TCR signaling and is likely mediated by inhibition of events that terminate the signaling response