We have a suspicion that you are an automated web bot software, not a real user.
To keep our site fast for other users, we have slowed down this page.
The slowdown will gradually disappear.
If you think this is a mistake, please contact us at genome-www@soe.ucsc.edu.
Also note that all data for hgGeneGraph can be obtained through our public MySQL server and
all our software source code is available and can be installed locally onto your own computer.
If you are unsure how to use these resources, do not hesitate to contact us.
Vitagliano et al., Cancer Res 2004
(MAP Kinase Signaling System...) :
Therefore, in thyroid cancer, RET/PTC mediated MAPK activation contributes to p27Kip1 deregulation
Mitsutake et al., Endocrinology 2006
(Carcinoma, Papillary...) :
BRAF mediates RET/PTC induced mitogen activated protein kinase activation in thyroid cells : functional support for requirement of the RET/PTC-RAS-BRAF pathway in papillary thyroid carcinogenesis ... The requirement for BRAF in RET/PTC mediated MAPK activation and gene expression has not been tested functionally ... These data indicate that BRAF is required for RET/PTC induced MAPK activation in thyroid cells and support the notion that BRAF inactivation may be an attractive target for PTCs
Iavarone et al., J Biol Chem 2006
(MAP Kinase Signaling System...) :
Activation of the Erk8 mitogen activated protein ( MAP ) kinase by RET/PTC3 , a constitutively active form of the RET proto-oncogene