Nakamura et al., Rheumatol Int 2007
(Sjogren's Syndrome) :
Chemical inhibition of PI3K-Akt by LY294002/wortmannin did not affect EGF mediated NF-kappaB p65 nuclear translocation ; and NF-kappaB inhibition by Bay 11-7082 did not suppress Akt phosphorylation
Wang et al., J Biol Chem 2010
:
Selective knockdown of EP2 or ectopic expression of EP3 blocks PKA- and PI3-K/Akt dependent p65 activation and markedly diminishes shear induced IL-6 expression
Harbrecht et al., Am J Physiol Gastrointest Liver Physiol 2012
(MAP Kinase Signaling System) :
NF-?B induces iNOS expression and can be regulated by Akt , but insulin had no effect on cytokine mediated I?Ba levels or NF-?B p65 translocation