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BCL3 — PDLIM7
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Nakamura et al., Virus Res 2008
:
The
latent membrane protein 1 (LMP1) encoded by Epstein-Barr virus
induces expression of the putative oncogene
Bcl-3 through activation of the nuclear factor-kappaB ... This LMP1 induced Bcl-3 expression is considered to be mediated by the transcription factor NF-kappaB, because ( 1 ) deletion of a critical NF-kappaB binding site in the Bcl-3 promoter abolished its responsiveness to LMP1, ( 2 ) an IkappaB mutant that specifically inhibits NF-kappaB activity suppressed the
LMP1 induced activation of the
Bcl-3 promoter, and ( 3 ) an LMP1 mutant lacking its effector domain CTAR2, required for the activation of NF-kappaB, is severely impaired in its ability to induce Bcl-3
Kung et al., J Virol 2008
:
In addition to activating the canonical and noncanonical pathways,
LMP1-CTAR1 constitutively activates STAT3 and
increases Bcl-3
Kung et al., J Virol 2011
:
EGFR transcription is induced by
LMP1 through a p50 NF?B1-Bcl-3 complex, and
Bcl-3 is
induced by LMP1 mediated activation of STAT3
Inoue et al., Nihon rinsho. Japanese journal of clinical medicine 1997
:
However,
regulation of the
Bcl-xL , Cdk4 and 6 and p27kip-1 expression by
LMP1 and the molecular mechanism of LMP1 mediated B cell transformation remain to be elucidated