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GRAP2 — IL18
Text-mined interactions from Literome
Ling et al., Crit Care Med 2002
:
In contrast to its effects on the janus kinase/STAT pathways,
interleukin-6 activation of MAP kinases ( extracellular signal regulated kinase-1, extracellular signal regulated kinase-2, and
p38 ) was unaffected by endotoxin
Yan et al., J Biol Chem 2002
:
This model probiotic also inhibits
activation of the pro-apoptotic
p38/mitogen activated protein kinase by tumor necrosis factor,
interleukin-1alpha , or gamma-interferon
Sekiyama et al., Immunity 2005
:
Inhibitors of caspase-1, reactive oxygen species, and
P38 mitogen activated protein kinase ( MAPK )
suppressed stress induced accumulation of plasma
IL-18
Niyonsaba et al., J Immunol 2005
(MAP Kinase Signaling System) :
The human beta-defensins ( -1, -2, -3, -4 ) and cathelicidin LL-37
induce IL-18 secretion through
p38 and ERK MAPK activation in primary human keratinocytes
Hewins et al., Kidney Int 2006
(Autoimmune Diseases...) :
Furthermore, TNFalpha and IL-18 phosphorylated neutrophil p38 mitogen activated protein kinase ( MAPK ), but
IL-18 mediated
p38 MAPK phosphorylation was unaffected by anti-TNFalpha antibody
Rasheed et al., Arthritis Res Ther 2010
(Osteoarthritis) :
Pomegranate extract inhibits the
interleukin-1ß induced activation of MKK-3,
p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes