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CTLA4 — IL10

Text-mined interactions from Literome

Chabot et al., J Immunol 1999 : By also measuring TNF-alpha levels, specificity of cytokine regulation was observed ; while anti-CD40 and CTLA-4-Fc reduced IL-10 and TNF-alpha levels, anti-CD23 did not affect TNF-alpha while attenuating IL-10 generation
Lee et al., J Immunol 2000 : Anti-CD154 mAb inhibited the production of IFN-gamma by 75 %, but did not inhibit IL-10 production, while CTLA4IgG4 completely inhibited the production of both IFN-gamma and IL-10
Chabot et al., J Neurosci Methods 2001 (Central Nervous System Diseases...) : Morphological features and mechanisms of cytokine production resemble those observed in microglia -- T cell co-cultures since CTLA-4 and CD40 -- CD40L blockades reduce TNF-alpha and IL-10 levels, while anti-CD23 inhibits IL-10 only in U937 -- T cell interactions
Riley et al., J Immunol 2001 : In addition to inhibiting cellular proliferation, CTLA-4 engagement prevented ICOS costimulated T cells from producing IL-4, IL-10 , and IL-13 ... Second, on preactivated cells that had high levels of ICOS expression, CTLA-4 ligation blocked the ICOS mediated induction of IL-4, IL-10 , and IL-13, suggesting an interference with downstream signaling pathways
Blazevic et al., J Clin Immunol 2001 : Inhibition studies using the B7-binding fusion protein CTLA4Ig and antibodies against CD80 and CD86 demonstrate that CTLA4Ig and anti-CD86 inhibited influenza-specific T cell proliferation, interleukin (IL)-2 and interferon (IFN)-gamma production, and generation of influenza-specific CD8+ CTL
Lazetic et al., J Biol Chem 2002 : In contrast, CTLA-4BP inhibited human mixed leukocyte reaction (MLR) and enhanced interleukin 10 production in MLR, supporting a role for CTLA-4BP in inducing T cell anergy and tolerance
Jovasevic et al., J Immunol 2004 (Plasmacytoma) : In this study, we show that engagement of CTLA-4 on tumor infiltrating lymphocytes from low-dose melphalan ( L-phenylalanine mustard ( L-PAM ) ) -treated MOPC-315 tumor bearers led to IL-10 secretion
Gregg et al., J Immunol 2005 (Diabetes Mellitus, Type 1) : IL-10 diminishes CTLA-4 expression on islet-resident T cells and sustains their activation rather than tolerance
Perez et al., J Immunol 2008 (Diabetes Mellitus, Type 1) : Induction of TGF-beta1 ( + ) and IL-10 ( + ) T cells was found to be independent of natural CD4 ( + ) CD25 ( + ) regulatory T cells, demonstrating that preferential ligation of CTLA-4 by CD80 induced IL-10 production by effector T cells, which in turn promoted the secretion of TGF-beta1
Elrefaei et al., PloS one 2009 : TGF-beta and IL-10 production by HIV-specific CD8+ T cells is regulated by CTLA-4 signaling on CD4+ T cells
Aronson et al., Am J Vet Res 2011 : Cyclosporine and cyclosporine-dexamethasone, but not human CTLA4-Ig , caused a significant decrease in IL-10 production
Ishimoto et al., Nephrol Dial Transplant 2013 (Nephrosis, Lipoid...) : In isolated glomeruli from mice injected with polyIC, expressions of CD80 and interleukin 10 significantly increased with a mild non-significant increase in CTLA-4 , and synaptopodin expression decreased significantly
Alegre et al., J Immunol 1998 : Inhibition of binding of CTLA-4 to its ligands using soluble anti-CTLA-4 mAb during stimulation with Ag increased the production not only of IL-2 by Th1 clones, but also that of IL-3 and IFN-gamma by Th1 clones and of IL-3, IL-4, IL-5, and IL-10 by Th2 clones