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LEP — STAR

Text-mined interactions from Literome

Cherradi et al., Endocrinology 2001 : We have demonstrated here that leptin significantly inhibits the expression of steroidogenic acute regulatory protein in primary cultures of rat adrenocortical cells
Ruiz-Cortés et al., Biol Reprod 2003 : Leptin at 1000 ng/ml inhibited SREBP1 induced StAR expression
Srivastava et al., Reproduction 2007 (Anovulation) : The in vitro study confirmed the in vivo observations of inhibitory effect of leptin on LH induced StAR expression and E2 production, whereas the stimulatory effect of leptin ( high dose ) on LH induced expression of insulin receptor protein and A4 production
Lin et al., Reproductive biology and endocrinology : RB&E 2009 : Furthermore, we show that leptin inhibits expression of the cAMP stimulated steroidogenic acute regulatory (StAR) protein, the rate limiting de novo protein in progesterone synthesis ... Moreover, siRNA mediated knock-down of the endogenous leptin receptor attenuates the effect of leptin on cAMP induced StAR protein expression and progesterone production, suggesting that the effect of leptin on steroidogenesis in granulosa cells is receptor dependent
Su et al., Reprod Sci 2012 (Fetal Hypoxia) : Therefore, we hypothesized that increases in plasma leptin will inhibit the expression of the ACTH-R, StAR , and steroidogenic enzymes and attenuate adrenal responsiveness in hypoxic fetuses ... Our results indicate that leptin blunts adrenal responsiveness in the late gestation hypoxemic fetus, and this effect appears mediated by decreased adrenal ACTH-R, StAR , and P450c21 expression