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CTNNB1 — DVL3
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Degradation of beta catenin:
WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2)
→
Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1)
(modification, inhibits)
Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3)
→
MYC (MYC)
(transcription, activates)
Gan et al., J Cell Biol 2008
Evidence: reporter gene, physical interaction
-
NCI Pathway Database Canonical Wnt signaling pathway:
beta catenin (CTNNB1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
beta catenin (CTNNB1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
DVL3 (DVL3)
(modification, collaborate)
Gan et al., J Cell Biol 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3)
(modification, collaborate)
Gan et al., J Cell Biol 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
JUN (JUN)
→
TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3)
(modification, collaborate)
Gan et al., J Cell Biol 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
DVL3 (DVL3)
→
TCF4/beta catenin/JUN/DVL3 complex (TCF7L2-CTNNB1-JUN-DVL3)
(modification, collaborate)
Gan et al., J Cell Biol 2008
Evidence: physical interaction
-
NCI Pathway Database Canonical Wnt signaling pathway:
WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2)
→
beta catenin (CTNNB1)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2)
→
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
beta catenin (CTNNB1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
NCI Pathway Database Canonical Wnt signaling pathway:
Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1)
→
WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A)
(modification, collaborate)
Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
Evidence: mutant phenotype
-
WikiPathways Wnt Signaling in Kidney Disease:
DVL2/DVL3/DVL1
→
CTNNB1
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
CTNNB1
—
DVL3
Strovel et al., J Biol Chem 2000
-
IRef Bind_translation Interaction:
CTNNB1
—
DVL3
(unspecified method)
Strovel et al., J Biol Chem 2000
-
IRef Biogrid Interaction:
CTNNB1
—
DVL3
(physical association, affinity chromatography technology)
Song et al., J Biol Chem 2000*
-
IRef Hprd Interaction:
CTNNB1
—
DVL3
(in vitro)
Song et al., J Biol Chem 2000*
-
IRef Hprd Interaction:
CTNNB1
—
DVL3
(in vivo)
Song et al., J Biol Chem 2000*
-
IRef Intact Interaction:
Complex of CTNNB1-AXIN1-PPM1A-DVL3
(association, anti bait coimmunoprecipitation)
Strovel et al., J Biol Chem 2000
-
IRef Intact Interaction:
Complex of 19 proteins
(association, anti bait coimmunoprecipitation)
Li et al., Cell 2012
-
IRef Mppi Interaction:
CTNNB1
—
DVL3
(coimmunoprecipitation)
Strovel et al., J Biol Chem 2000
-
IRef Ophid Interaction:
CTNNB1
—
DVL3
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
González-Sancho et al., Mol Cell Biol 2004
:
Unlike the effects of Wnt1, phosphorylation of Dvl in response to Wnt5a is not concomitant with beta-catenin stabilization, indicating that
Dvl phosphorylation is not
sufficient to activate canonical
Wnt/beta-catenin signaling
Yau et al., Oncogene 2005
(Carcinoma, Hepatocellular...) :
Dishevelled ( Dvl ) , a key activator of the pathway, inhibits the adenomatous polyposis coli complex, and this
leads to the accumulation of
beta-catenin and promotes tumorigenesis
Bryja et al., Cell Signal 2007
:
Thus, our results show that Wnt-3a rapidly induce a partial activation of beta-catenin in the absence of PS-Dvl at low doses, while at high doses induce a full activation of
beta-catenin in a
PS-Dvl dependent manner
Wei et al., Lung Cancer 2008
(Carcinoma, Non-Small-Cell Lung...) :
We also examined the
effect of Dvl-1 and
Dvl-3 overexpression on
beta-catenin expression and the invasive ability of A549 and QG56 lung cancer cells
Gnad et al., Molecular cancer 2010
(Helicobacter Infections) :
We analysed the H. pylori induced activation of Wnt signaling factors and demonstrate for the first time that the canonical Wnt signaling proteins LRP6 and Dvl2 and
Dvl3 are
involved in the regulation of
beta-catenin
Zhang et al., Cell Signal 2010
:
Among these,
Dishevelled ( Dvl ) is a critical regulator that releases beta-catenin from degradation and
stabilizes TCF4/beta-catenin complex