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IFNG — MAPK1

Pathways - manually collected, often from reviews:

• KEGG Natural killer cell mediated cytotoxicity: MAPK1/MAPK3 → IFNG (protein-protein, indirect effect)
• NCI Pathway Database IL2-mediated signaling events: Erk1-2-active (MAPK3/MAPK1) → IFN-gamma (IFNG) (transcription, activates) Yu et al., J Immunol 2000*, Trinchieri et al., J Exp Med 1984*
  Evidence: mutant phenotype

Text-mined interactions from Literome

Takaoka et al., EMBO J 1999 : In this paper we demonstrate that Pyk2, which belongs to another PTK family, is critical for the Jak mediated MAPK and Stat1 activation by IFN-gamma , but not IFN-alpha
Kim et al., J Biol Chem 1999 : Notably, leukemia inhibitory factor, but not interferon-gamma , also promoted ErbB-2 shift and mitogen activated protein kinase activation
Wang et al., Hypertension 1999 (MAP Kinase Signaling System) : Tumor necrosis factor-alpha (TNF-alpha) alone can induce extracellular signal regulated kinase ( ERK ), p38 MAPK , and c-Jun N-terminal kinase activity in a rapid and transient manner, whereas interferon-gamma (IFN-gamma) can induce only ERK
Nguyen et al., Biochem J 2000 : In contrast with the JAK-STAT signalling pathway, acute ethanol exposure significantly potentiated IFN-beta or IFN-gamma induced activation of p42/44 MAPK , and caused marked activation of protein kinase C ( PKC )
Zhang et al., J Immunol 2000 : The activation of p38 MAPK is required for normal induction of IFN-gamma mRNA and IFN-gamma secretion by IL-12 in activated T cells and Th1 cells
Badou et al., Eur J Immunol 2001 (Calcium Signaling...) : We show that : ( 1 ) the calcium response is identical following weak and strong TCR stimulation ; ( 2 ) mitogen activated protein kinase ( MAPK ) activation is a gradual phenomenon depending upon the strength of TCR activation ; ( 3 ) a calcium response, even weak, triggers IL-4 expression ; ( 4 ) IFN-gamma synthesis requires not only a calcium response but also MAPK activation ... The MAPK pathway is dispensable for IL-4 production, although it amplifies IL-4 synthesis upon strong TCR stimulation ; ( 5 ) TCR induced IL-4 production also depends on calcium signaling in Th2 cells, while IFN-gamma synthesis is dependent , in addition, on MAPK activation in Th1 cells
Chae et al., Res Commun Mol Pathol Pharmacol 2001 : However, a specific inhibitor of p38 MAPK , SB203580, had no effect on TNF-alpha/IFN-gamma or LPS/IFN-gamma induced NF-kappaB activation
Choudhury et al., J Biol Chem 2004 (MAP Kinase Signaling System) : In addition to activating PKCepsilon, IFN-gamma increased MAPK activity, resulting in transcriptional activation of Elk-1, a nuclear target of MAPK ... Ly294002 or a dominant negative PI 3-kinase significantly blocked IFN-gamma induced MAPK activity ... IFN-gamma stimulated MAPK phosphorylated STAT1alpha in vitro
Harigai et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid...) : Stimulation with rsCD154 plus IFNgamma induced the activation of ERK-1/2, p38 MAPK , and NF-kappaB ... Stimulation with rsCD154 plus IFNgamma induced the activation of ERK-1/2 , p38 MAPK, and NF-kappaB
Chang et al., J Cell Biochem 2004 : Immunobloting reveals that LIGHT/IFN-gamma could induce p38 MAPK activity, Bak and Fas expression, but down-regulate Mcl-1
Venkatesan et al., Cell Signal 2006 : Finally, expression of dominant negative Akt kinase blocked IFN-gamma stimulated MAPK activation
Giannopoulou et al., American journal of physiology. Renal physiology 2006 (Fibrosis...) : Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 action ... Stimulation of HKC cells with IFN-gamma triggered a sustained activation of Erk-1/2 and signal transducer and activator of transcription-3 ( Stat3 )
Kalvakolanu et al., J Interferon Cytokine Res 2005 (MAP Kinase Signaling System) : At least two IFN-gamma induced MAPK signals converge on to C/EBP-beta for inducing transcription
Pennini et al., J Immunol 2006 (MAP Kinase Signaling System) : Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling
Rakshit et al., J Bone Joint Surg Am 2006 (Osteolysis) : In contrast, titanium inhibition of interferon-gamma signaling is not dependent on mitogen activated protein kinase activation and is accompanied by only modest induction of the interferon-gamma inhibitor SOCS1
Yao et al., J Immunol 2006 (MAP Kinase Signaling System) : In this study, we report that both constitutive and IFN-gamma-inducible expression of CIITA in mouse bone marrow derived dendritic cells ( DC ) and macrophages, respectively, are regulated by MAPK signals
Koch et al., Respir Med 2007 (Asthma) : IL-12 induced T-bet expression and IFNgamma release in lymphocytes from asthmatics -- role of MAPkinases ERK-1/-2, p38 ( MAPK ) and effect of dexamethasone ... IL-12 induced T-bet expression and IFNgamma release in lymphocytes from asthmatics -- role of MAPkinases ERK-1/-2 , p38 ( MAPK ) and effect of dexamethasone ... IFNgamma production was dependent on phosphorylation of ERK-1/-2 and p38MAPK , as examined by PD098059, an inhibitor of the upstream activator of MAPKkinase ( MKK-1 ), and SB203580, an inhibitor of p38MAPK ... IFNgamma production was dependent on phosphorylation of ERK-1/-2 and p38MAPK, as examined by PD098059, an inhibitor of the upstream activator of MAPKkinase ( MKK-1 ), and SB203580, an inhibitor of p38MAPK ... In conclusion, ( 1 ) p38MAPK-pathway rather than ERK-pathway may play a more basic role in the regulation of the increased T-bet expression in asthma, and ( 2 ) ERK- and p38MAPK-activation modulate IFNgamma expression independently of T-bet and this regulatory role of ERK-1/-2 on IFNgamma release is impaired in asthma ... In conclusion, ( 1 ) p38MAPK-pathway rather than ERK-pathway may play a more basic role in the regulation of the increased T-bet expression in asthma, and ( 2 ) ERK- and p38MAPK-activation modulate IFNgamma expression independently of T-bet and this regulatory role of ERK-1/-2 on IFNgamma release is impaired in asthma
Ranjbaran et al., J Immunol 2007 (Arteritis...) : In contrast to cognate stimuli, IL-12/IL-18 dependent IFN-gamma secretion was prevented by a p38 MAPK inhibitor and not by cyclosporine
Kanda et al., Endocrinology 2007 (MAP Kinase Signaling System...) : Prolactin induced phosphorylation of JAK2 and ERK, whereas IFN-gamma induced phosphorylation of JAK1, JAK2, and p38 MAPK
Akilov et al., J Leukoc Biol 2007 (Disease Models, Animal...) : Inhibition of MP responses is a hallmark of Leishmania infection ; our data demonstrate further that host MR is not essential for blocking IFN-gamma/LPS induced IL-12 production and MAPK activation by Leishmania
Kanda et al., Eur J Immunol 2007 : IL-18 induced phosphorylation of ERK and Akt, while IFN-gamma induced phosphorylation of p38 MAPK
Wang et al., Endocrinology 2007 : In addition, our results showed that IFN-gamma/IL-1beta enhance p38 MAPK phosphorylation and that SB 203580, a p38 MAPK inhibitor, can inhibit IFN-gamma/IL-1beta induced p38 MAPK phosphorylation
Girart et al., J Immunol 2007 (Melanoma) : Also, secretion of IFN-gamma was dependent on MEK1/ERK, p38 MAPK , p70 ( S6 ) kinase, and NF-kappaB, but not on calcineurin
Noubade et al., J Clin Invest 2007 (Encephalomyelitis, Autoimmune, Experimental...) : Moreover, H1R signaling at the time of TCR ligation was required for activation of p38 MAPK , a known regulator of IFN-gamma expression
Yoo et al., Neurochem Int 2008 (Encephalitis...) : LPS+IFN-gamma induced p38 MAPK activation and ONOO ( - ) generation were attenuated by SB203580 or SKF-86002, specific inhibitors of p38 MAPK
Suzuki et al., Cytokine 2008 (Hemorrhage...) : Two hours thereafter, T cell production of IL-2 and IFN-gamma and activation of MAPK ( p38, ERK-1/2 and JNK ) were determined
Goleva et al., Am J Respir Cell Mol Biol 2009 : The presence of the p38 MAPK inhibitor, SB203580, or IFN-gamma inhibited p38 MAPK phosphorylation and enhanced GCRalpha nuclear translocation in response to DEX
Jiang et al., Clin Exp Immunol 2009 (Rheumatic Heart Disease) : At the same time, p38 mitogen activated protein kinase was involved in TNF-alpha and IFN-gamma induced TN-C transcription
Grzelkowska-Kowalczyk et al., Cell Mol Biol Lett 2010 : The aim of this study was to compare the effects of TNF-alpha, IL-1beta and IFN-gamma on the activation of protein kinase B (PKB), p70 ( S6k ), mitogen activated protein kinase ( MAPK ) and p90 ( rsk ), and on IGF-I stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes
Grzelkowska-Kowalczyk et al., Cell Biol Int 2010 : The purpose of the present study was to examine the potential effect of IFN-gamma ( interferon-gamma ) on the cellular content and phosphorylation of PKB ( protein kinase B ), p70S6k ( p70 S6 kinase ) and MAPK ( mitogen activated protein kinase ), and on the ability of insulin to stimulate the glucose uptake and protein synthesis in mouse C2C12 myotubes
Matsumiya et al., J Immunol 2010 : TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target, MAPK activated protein kinase-2, but IFN-gamma did not affect the levels of MAPK and MAPK activated protein kinase-2 phosphorylation induced by TNF-alpha
Ding et al., J Immunol 1994 : IFN-gamma induced tyrosine phosphorylation of MAPK , an early activation event, was undetectable in macrophages from the aged mice
Ding et al., J Immunol 1993 : c ) Macrophages from C3H/HeJ mice, which carry a defective Lps gene, fail to activate MAPK in response to taxol or LPS, although they activate MAPK in response to insulin or IFN-gamma
Nishiya et al., FEBS Lett 1997 (Glioma) : Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-gamma induced MAPK activation that is mediated by p21ras
Rose et al., Biochem Biophys Res Commun 1997 : These modulatory effects of IFN-gamma and TGF-beta on MAPK activation correlated with changes in Fc gamma R-stimulated TNF-alpha production by these two cytokines