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IL6 — SERPINA3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SERPINA3 → IL6 (increases)
  Evidence: in human hepatoma cells, IL6 stimulated the synthesis of beta-fibrinogen, alpha1-antichymotrypsin, alpha1-acid glycoprotein and haptoglobin

Text-mined interactions from Literome

Kino et al., J Allergy Clin Immunol 2007 : TB-2-081, and to a lesser extent TB-2-082, suppressed IL-6 induced alpha1-antichymotrypsin (AACT) mRNA expression in HepG2 cells, whereas TB-2-081 failed to influence the mRNA expression of the TNF-alpha induced mRNA expression of the methionine adenosyltransferase 2A gene in these cells ... The soluble glycoprotein 130, but not the soluble IL-6 receptor, antagonized TB-2-081 induced suppression of IL-6 stimulated AACT mRNA expression
Kino et al., Eur J Clin Invest 2007 (Acute-Phase Reaction...) : Results GW501516 dose-dependently suppressed interleukin-6 induced mRNA expression of the acute phase protein alpha1-antichymotrypsin in HepG2 cells ... Depletion of the PPARdelta receptor, but not of PPARalpha or gamma, attenuated the suppressive effect of GW501516 on interleukin-6 induced alpha1-antichymotrypsin mRNA expression, indicating that PPARdelta specifically mediated this effect
May et al., Biochem Biophys Res Commun 1989 : Cytokines like interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor (TNF) as well as bacterial products such as the lipopolysaccharide (LPS) rapidly enhance production of biologically active IL-6 by HUVEC ( IL-6 bioassay : increase in alpha 1-antichymotrypsin secretion by Hep3B2 cells and its neutralization by antiserum to E. coli derived human IL-6 )
Wang et al., J Biol Chem 1995 (Carcinoma, Hepatocellular...) : Hepatoma cell lines stably expressing the Val-135 temperature-sensitive mutant of murine p53 ( wt-like at 32.5 degrees C and mutant-like at 37 degrees C ) were derived from Hep3B cells and tested for the temperature-sensitive phenotype of their ability to synthesize and secrete fibrinogen and alpha 1-antichymotrypsin in response to IL-6
Kasza et al., Biol Chem Hoppe Seyler 1994 (Acute-Phase Reaction) : Interleukin-6 maximally stimulated synthesis of alpha-1-antichymotrypsin between days 1 and 3 whereas the response of fibrinogen was delayed to days 3 to 7 ... Retinoic acid increased the effect of IL-6 on alpha-1-antichymotrypsin (ACT) and fibrinogen (FBG) on the level of both proteins and mRNAs
Bartalena et al., Endocrinology 1993 (Carcinoma, Hepatocellular...) : Interleukin-6 (IL-6) , the main mediator of the acute phase phenomenon, increases alpha 1-antitrypsin and alpha 1-antichymotrypsin synthesis and decreases T4-binding globulin synthesis by human hepatoblastoma derived ( Hep G2 ) cells
Machein et al., Neuroreport 1995 (Astrocytoma) : IL-1 beta and TNF alpha, but not IL-6 , induce alpha 1-antichymotrypsin expression in the human astrocytoma cell line U373 MG ... We have studied the effects of IL-1, IL-6 and TNF alpha on the expression of the acute-phase protein alpha 1-antichymotrypsin (ACT) in human astrocytoma cell lines
Wigmore et al., Ann Surg 1997 : Eicosapentaenoic and gammalinolenic significantly increased interleukin-6 stimulated production of C-reactive protein and alpha 1-antichymotrypsin but reversed the stimulatory effect of interleukin-6 on haptoglobin production
Kordula et al., J Biol Chem 1998 (Alzheimer Disease) : Oncostatin M and the interleukin-6 and soluble interleukin-6 receptor complex regulate alpha1-antichymotrypsin expression in human cortical astrocytes