Gene interactions and pathways from curated databases and text-mining

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CCR2 — MAPK3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK3 → CCR2 (increases) Nanki et al., J Immunol 2001*
    Evidence: Treatment of fibroblast-like synoviocyte (FLS) cultures with RS-504393, a CCR-2 antagonist significantly inhibited the CCL-2 induced ERK1 activation, indicating that CCL-2 induced ERK1 activation was mediated by CCR-2.

Text-mined interactions from Literome

Hirata Terra et al., Anal Biochem 2004 : MCP-1 induced phosphorylation of p44/42 MAPK is dependent upon the expression of CCR2B
Choi et al., Fitoterapia 2011 (Leukemia, Monocytic, Acute) : Herein, we investigated the effects of Rh1 on the expression of MCP-1 and CCR2 , activation of MAPK signaling, and chemotaxis of monocytes