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CDKN1A — KAT2B

Text-mined interactions from Literome

Zhao et al., Oncogene 2003 : In vivo, coexpression of wild-type, but not HAT-deficient PCAF with p73beta markedly increases p21 expression
Love et al., Cell cycle (Georgetown, Tex.) 2012 : The histone acetyltransferase PCAF regulates p21 transcription through stress induced acetylation of histone H3 ... PCAF was required for the transcriptional activation of p21 in response to exogenous p53 in p53-null cells, nutlin-3, DNA damaging agents and p14(ARF) expression, suggesting a broad requirement for PCAF in p53 signaling to p21 after stress ... Surprisingly, the role for PCAF in induction of p21 was independent of p53 lysine 320 acetylation, a previously suggested target of PCAF mediated acetylation ... Though p21 promoter occupancy by p53 was not altered by PCAF knockdown, activation of p21 transcription required an intact PCAF HAT domain, and induction of chromatin marks acetyl-H3K9 and acetyl-H3K14 at the p21 promoter by p53 was dependent upon physiologic levels of PCAF
Scolnick et al., Cancer Res 1997 (Breast Neoplasms) : Furthermore, CBP and P/CAF enhanced the ability of p53 to activate expression of the endogenous p21 ( cip1/waf1 ) gene, whereas E1A and dominant negative CBP mutants suppressed p53 dependent p21 ( cip1/waf1 ) expression