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FOS — IL12B
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
FOS
—
IL12B
(interaction, mapped from kegg_pathways)
-
STRING interaction:
IL12B
—
FOS
(interaction, mapped from kegg_pathways)
Text-mined interactions from Literome
Sugimoto et al., Eur J Immunol 2003
:
IL-18, but not
IL-12 ,
induced activator protein-1 (AP-1) responsible for high levels of IFN-gamma promoter activation
Ma et al., J Immunol 2004
:
The
role of
AP-1 in
IL-12p40 transcription was confirmed by using antisense c-fos and c-jun oligonucleotides ... Taken together, our results suggest that DXM may
inhibit IL-12p40 production in LPS stimulated human monocytic cells by down regulating the activation of JNK MAPK, the
AP-1 , and NF-kappaB transcription factors
Park et al., Int Immunol 2004
:
IL-12 stimulation greatly
enhanced the promoter binding activity of
c-Jun/AP-1 , a critical transcription factor for IFN-gamma gene expression in wild-type T cells, but not in STAT4-deficient ( STAT4 ( -/- ) ) T cells
Matsumoto et al., J Immunol 2004
(Inflammation) :
This occurs via a c-Fos- and c-Jun based mechanism ; we demonstrate that ectopic expression of c-Jun activates the IL-12p40 promoter, whereas expression of
c-Fos inhibits
IL-12p40 promoter activity ... Simvastatin prevents LPS induced c-Fos expression, thereby relieving the inhibitory
effect of
c-Fos on the
IL-12p40 promoter
Tomczak et al., J Immunol 2006
(MAP Kinase Signaling System) :
Instead, it was linked to the induction of
c-Fos , a known
inhibitor of
IL-12 p40 expression
Ma et al., J Biol Chem 2009
(Acquired Immunodeficiency Syndrome) :
We have previously shown that lipopolysaccharide (LPS) induced
IL-12p40 production in monocytic cells is
regulated by NFkappaB and
AP-1 transcription factors through the activation of two distinct upstream signaling pathways, namely the c-Jun-N-terminal kinase (JNK) and the calmodulin dependent protein kinase-II activated pathways
Azzoni et al., J Immunol 1998
:
We previously demonstrated that expression of transcription factors ( e.g., Egr-1, JunB, and
c-Fos ) is differentially
regulated by IL-2 and
IL-12