Korashy et al., J Biochem Mol Toxicol 2008
(MAP Kinase Signaling System) :
In the current study, we examined the role of redox-sensitive transcription factors, NF-kappaB and AP-1 signaling pathways in the modulation of Nqo1 by heavy metals
Wilkinson et al., Biochem Biophys Res Commun 1998
:
Disruption of c-Fos leads to increased expression of NAD(P)H:quinone oxidoreductase1 and glutathione S-transferase ... In the present report, we used c-Fos-/- mice and investigated the physiological ( in vivo ) role of c-Fos in repression of the NQO1 and GST genes expression ... These results confirm a negative ( repressive ) role for c-Fos in the expression of NQO1 , GST Ya, and other detoxifying enzyme genes