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CD4 — ZAP70

Pathways - manually collected, often from reviews:

• BioCarta t cell receptor signaling pathway: TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK) → ZAP70 (modification, collaborate)
• BioCarta t cell receptor signaling pathway: TCR-CD3/MHC II/CD4/LCK complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK) → TCR-CD3/MHC II/CD4/LCK/ZAP70 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  
• BioCarta t cell receptor signaling pathway: ZAP70 → TCR-CD3/MHC II/CD4/LCK/ZAP70 complex (TRA@-TRB@-CD3Z-CD3G-CD3E-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  
• BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/ZAP70/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-ZAP70-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) (modification, collaborate)
  
• BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/ZAP70/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-ZAP70-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → ZAP70 (modification, collaborate)
• BioCarta activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor: CD3Z antigen zeta polypeptide/MHC class II alpha/CD4/LCK/CD3Z antigen zeta polypeptide/TCR-alpha/TCR-beta/CD3G antigen gamma polypeptide/CD3E antigen epsilon polypeptide/CD3E antigen epsilon polypeptide/CD3D antigen delta polypeptide/MHC IIb complex (CD3Z-HLA-DRA-CD4-LCK-TRA@-TRB@-CD3G-CD3E-CD3D-HLA-DRB1) → ZAP70 (modification, collaborate)
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → ZAP-70 (ZAP70) (modification, collaborate) Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-CD247) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: B7 family/CD28 complex (CD28-CD80_CD86) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, activates)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: ZAP-70 (ZAP70) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Pelosi et al., J Biol Chem 1999, Iwashima et al., Science 1994, Chan et al., J Immunol 1994, van Oers et al., J Exp Med 1996, Tuosto et al., Eur J Immunol 1998
  Evidence: mutant phenotype, assay
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: SHP2 (PTPN11) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, inhibits)
  Kwon et al., EMBO J 2005, Han et al., Science 1998, Michel et al., J Biol Chem 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: Fyn (FYN) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, activates)
  Kwon et al., EMBO J 2005, Han et al., Science 1998, Michel et al., J Biol Chem 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2) → CBL (CBL) (modification, collaborate) Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2) → SLAP-2 (SLA2) (modification, collaborate) Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/CBL/SLAP-2/Ubiquitin complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-CBL-SLA2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: CBL (CBL) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: SLAP-2 (SLA2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Wang et al., J Biol Chem 2001, Loreto et al., Mol Cell Biol 2002
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: LAT/GRAP2/SLP76 complex (LAT-GRAP2-LCP2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Liu et al., J Immunol 2000
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: HPK1 (MAP4K1) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Liu et al., J Immunol 2000
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2) → 3BP2 (SH3BP2) (modification, collaborate) Deckert et al., Immunity 1998
  Evidence: physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Deckert et al., Immunity 1998
  Evidence: physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: 3BP2 (SH3BP2) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Deckert et al., Immunity 1998
  Evidence: physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: CSK/PAG1 complex (CSK-PAG1) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, collaborate)
  Brdicka et al., J Exp Med 2000
  Evidence: assay, physical interaction
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: SHP1 (PTPN6) → TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2) (modification, activates)
  Yu et al., FEBS J 2006
  Evidence: mutant phenotype
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: TCR/CD3/MHC II/CD4/LCK/ZAP-70/3BP2 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70-SH3BP2) → None (modification, activates) Deckert et al., Immunity 1998
  Evidence: reporter gene
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: ITK (ITK) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, activates)
  Paz et al., Biochem J 2001, Perez-Villar et al., Biochemistry 2002, Zhang et al., Cell 1998
  Evidence: assay
• Reactome Reaction: CD4 → ZAP70 (reaction) Mustelin et al., Biochem J 2003, van Oers et al., Semin Immunol 1995, Chu et al., Immunol Rev 1998
• Reactome Reaction: CD4 → ZAP70 (indirect_complex) Mustelin et al., Biochem J 2003, van Oers et al., Semin Immunol 1995, Chu et al., Immunol Rev 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CD4 — ZAP70 (physical association, affinity chromatography technology) Thome et al., J Exp Med 1995*

Text-mined interactions from Literome

Mahon et al., Cell Immunol 2012 : We have shown previously that M. tuberculosis cell wall glycolipids, including mannose capped lipoarabinomannan ( ManLAM ), directly inhibit polyclonal murine CD4 ( + ) T cell activation by blocking ZAP-70 phosphorylation
Guntermann et al., J Acquir Immune Defic Syndr Hum Retrovirol 1997 : Human immunodeficiency virus infection abolishes CD4 dependent activation of ZAP-70 by inhibition of p56lck