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CD28 — MAPK3

Text-mined interactions from Literome

Zhang et al., J Immunol 1999 : In contrast to that reported for human Jurkat T cells, we found that p38 MAPK , but not Jun NH2-terminal kinase (JNK), is weakly activated upon stimulation with either anti-CD3 or anti-CD28 in murine thymocytes and splenic T cells ... However, p38 MAPK is activated strongly and synergistically by either CD3/CD28 coligation or PMA/Ca2+ ionophore stimulation, which mimics TCR-CD3/CD28 mediated signaling
Marti et al., J Immunol 2001 : TCR and CD28 costimulatory receptor-cooperative induction of T cell IL-2 secretion is dependent upon activation of mitogen activated protein ( MAP ) kinases
Yu et al., J Immunol 2001 (MAP Kinase Signaling System) : Notably, CD28 ligation activated p38 MAPK and CaMKIV, the kinases stimulated by CD3 engagement, suggesting that CD28 acts by increasing the activation extent of p38 MAPK and CaMKIV
Perchonock et al., Mol Cell Biol 2006 (Splenomegaly) : While TCR/CD28 mediated activations of phosphotyrosine induction, extracellular signal regulated kinase 1/2 , Jun N-terminal protein kinase, IkappaB kinase alpha/beta, and Akt were unaltered, constitutive activation of p38 mitogen activated protein kinase and its upstream regulators MKK3/6 were observed for ALX-deficient splenocytes