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CREB3 — IRS2
Text-mined interactions from Literome
Jhala et al., Genes Dev 2003
(Diabetes Mellitus...) :
cAMP promotes pancreatic beta-cell survival via
CREB mediated
induction of
IRS2
Costes et al., Diabetes 2006
:
cAMP-responsive element binding protein (
CREB ) is
required for beta-cell survival by regulating expression of crucial genes such as bcl-2 and
IRS-2
Liu et al., PloS one 2012
(Diabetes Mellitus, Type 2) :
This study investigated whether CaMK4 is also a potential target to increase ß-cell mass through
CREB mediated
IRS-2 expression, by quantifying mouse MIN6 ß-cell proliferation and apoptosis following IRS-2 knockdown, CaMKs inhibition and alterations in CaMK4 and CREB expression