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GSK3B — SYT1
Text-mined interactions from Literome
Dugo et al., Crit Care Med 2005
(Endotoxemia...) :
GSK-3beta inhibition
reduced the Ser536 phosphorylation of nuclear factor-kappaB subunit
p65 and the messenger RNA expression of nuclear factor-kappaB dependent proinflammatory mediators but had no effect on the nuclear factor-kappaB/DNA binding activity in the lung ...
GSK-3beta inhibition
reduced the increase in nuclear factor-kappaB
p65 activity caused by interleukin-1 in human embryonic kidney cells in vitro
Steinbrecher et al., Mol Cell Biol 2005
:
We show that efficient localization of
p65 to the promoter regions of the interleukin-6 and monocyte chemoattractant protein 1 genes following tumor necrosis factor alpha treatment
requires GSK-3beta
Dugo et al., Novartis Found Symp 2007
(Endotoxemia...) :
GSK-3beta inhibition
reduced the increase in NF-kappaB
p65 activity caused by interleukin (IL)1 in human e mbryonic kidney cells in vitro
Ma et al., Toxicol Lett 2009
(Lung Diseases) :
Next, we further observed that constitutively active
GSK3beta stabilized the inhibitor of NF-kappaB ( IkappaBalpha ),
inhibited p65 nuclear translocation and partially blocked BLM induced NF-kappaB activation