Gene interactions and pathways from curated databases and text-mining

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GSK3B — SYT1

Text-mined interactions from Literome

Dugo et al., Crit Care Med 2005 (Endotoxemia...) : GSK-3beta inhibition reduced the Ser536 phosphorylation of nuclear factor-kappaB subunit p65 and the messenger RNA expression of nuclear factor-kappaB dependent proinflammatory mediators but had no effect on the nuclear factor-kappaB/DNA binding activity in the lung ... GSK-3beta inhibition reduced the increase in nuclear factor-kappaB p65 activity caused by interleukin-1 in human embryonic kidney cells in vitro
Steinbrecher et al., Mol Cell Biol 2005 : We show that efficient localization of p65 to the promoter regions of the interleukin-6 and monocyte chemoattractant protein 1 genes following tumor necrosis factor alpha treatment requires GSK-3beta
Dugo et al., Novartis Found Symp 2007 (Endotoxemia...) : GSK-3beta inhibition reduced the increase in NF-kappaB p65 activity caused by interleukin (IL)1 in human e mbryonic kidney cells in vitro
Ma et al., Toxicol Lett 2009 (Lung Diseases) : Next, we further observed that constitutively active GSK3beta stabilized the inhibitor of NF-kappaB ( IkappaBalpha ), inhibited p65 nuclear translocation and partially blocked BLM induced NF-kappaB activation