Schulze et al., Circulation 2003
(Acute Disease...) :
Loss of TIMP-4 from the cardiac myocyte leads to an increase in net myocardial MMP activity that contributes to acute myocardial stunning injury
Camp et al., J Hypertens 2003
(Glomerulosclerosis, Focal Segmental...) :
The increased levels of TIMP-4 in the medulla may inhibit the collagenolytic activity of MMP but is unable to inhibit the elastinolytic activity
Fernández et al., Biochem Biophys Res Commun 2006
:
Despite the importance of MMP activity in the regulation of angiogenesis, relatively little is known about the role of TIMP-4 , the most recently discovered endogenous MMP inhibitor , in modulating neovascularization