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BIRC6 — CASP9
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
CASP9
—
BIRC6
(coimmunoprecipitation)
Hao et al., Nat Cell Biol 2004*
-
IRef Bind_translation Interaction:
CASP9
—
BIRC6
(experimental interaction detection)
Hao et al., Nat Cell Biol 2004*
-
IRef Bind_translation Interaction:
CASP9
—
BIRC6
(coimmunoprecipitation)
Bartke et al., Mol Cell 2004
-
IRef Biogrid Interaction:
CASP9
—
BIRC6
(direct interaction, enzymatic study)
Qiu et al., J Biol Chem 2005
-
IRef Biogrid Interaction:
CASP9
—
BIRC6
(physical association, affinity chromatography technology)
Hao et al., Nat Cell Biol 2004*
-
IRef Biogrid Interaction:
CASP9
—
BIRC6
(physical association, affinity chromatography technology)
Bartke et al., Mol Cell 2004
-
IRef Biogrid Interaction:
CASP9
—
BIRC6
(direct interaction, pull down)
Qiu et al., J Biol Chem 2005
-
IRef Biogrid Interaction:
CASP9
—
BIRC6
(physical association, affinity chromatography technology)
Qiu et al., J Biol Chem 2005
-
IRef Hprd Interaction:
CASP9
—
BIRC6
(in vitro)
Hao et al., Nat Cell Biol 2004*
-
IRef Innatedb Interaction:
BIRC6
—
CASP9
(unknown, -)
Hao et al., Nat Cell Biol 2004*
-
IRef Ophid Interaction:
BIRC6
—
CASP9
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Bartke et al., Mol Cell 2004
:
By using wild-type and mutant forms we show that
BRUCE inhibits
caspase activity and apoptosis depending on its BIR domain
Qiu et al., J Biol Chem 2005
:
Through these associations,
BRUCE promotes the degradation of Smac and
inhibits the activity of
caspase-9 but not the effector caspase, caspase-3
Das et al., Cancer 2007
(Glioblastoma) :
Other events in apoptosis included overexpression of Bax, down-regulation of Bcl-2 and some
BIRC proteins, mitochondrial release of cytochrome c and Smac into the cytosol, and
activation of calpain,
caspase-9 , and caspase-3
Das et al., Brain Res 2008
(Brain Neoplasms...) :
Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c and Smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing (
BIRC ) molecules, an increase in intracellular free [Ca2+ ], and
activation of calpain and
caspase-3
Karmakar et al., Neuroscience 2009
(Body Weight...) :
Combination of 4-HPR and GST increased Bax : Bcl-2 ratio, mitochondrial release of Smac, downregulation of baculovirus inhibitor-of-apoptosis repeat containing (
BIRC ) proteins including BIRC-2 and BIRC-3, and activation of
caspase-3 and apoptosis
inducing factor ( AIF )