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CSF1R — IL3
Text-mined interactions from Literome
Suzuki et al., Am J Hematol 2004
:
GM-CSF or
IL-3 down-regulated the expression of
M-CSFR ... These data demonstrate that GM-CSF and
IL-3 primarily support the differentiation of monocytes into DCs and inhibit M-CSF dependent differentiation into macrophages by
suppressing the expression of
M-CSFR , thereby promoting differentiation into DCs
Yogesha et al., J Biol Chem 2005
:
In osteoclast precursors,
IL-3 and GM-CSF
inhibited c-Fms expression post-transcriptionally
Gupta et al., J Immunol 2010
(Bone Resorption) :
To investigate the mechanism of IL-3 action, we analyzed the
effect of
IL-3 on the receptor activator of NF-kappaB and
c-Fms receptors and c-Fos, PU.1, NFAT cytoplasmic 1, and RelB transcription factors essential for osteoclastogenesis ...
IL-3 significantly
inhibited c-Fms and downregulated both PU.1 and c-Fos at both mRNA and protein level
Chen et al., J Immunol 1986
:
Binding studies with radioactive labeled CSF-1 ( 125I-CSF-1 ) showed that
IL 3 treatment
induced an increased expression of
CSF-1 receptor activity by PEM which appears to be a result of increased number of available receptor sites