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CDKN1A — NOTCH1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Rangarajan et al., EMBO J 2001
:
In differentiating primary keratinocytes in vitro endogenous
Notch1 is
required for induction of
p21WAF1/Cip1 expression, and activated Notch1 causes growth suppression by inducing p21WAF1/Cip1 expression ... The RBP-Jkappa protein binds directly to the endogenous p21 promoter and
p21 expression is
induced specifically by activated
Notch1 through RBP-Jkappa dependent transcription
Noseda et al., Mol Cell Biol 2004
:
Activated
Notch inhibits mitogen induced upregulation of
p21Cip1 and delays cyclin D-cdk4 mediated Rb phosphorylation ...
Notch dependent repression of
p21Cip1 prevents nuclear localization of cyclin D and cdk4
Mammucari et al., Dev Cell 2005
(Alopecia) :
Induction of the
p21 ( WAF1/Cip1 ) gene by
Notch 1 activation in differentiating keratinocytes is associated with direct targeting of the RBP-Jkappa protein to the p21 promoter
Duan et al., Biol Cell 2006
(Tongue Neoplasms) :
Activated
Notch1 also
led to dramatic increase in
p21 ( WAF1/CIP1 ) and p53 expression with decreases in Skp2 ( S-phase kinase associated protein 2 ) and Bcl-2 ( B-cell lymphocytic-leukaemia proto-oncogene 2 ) expression, which may participate in the induction of apoptosis and cell cycle arrest
Rooman et al., Am J Pathol 2006
(Metaplasia) :
Chemical inhibition of
Notch signaling
resulted in increased proliferation and induction of the cell-cycle regulator
p21Cip1
Henning et al., Cell Death Differ 2008
:
Induction of the
p21 ( cip/waf ) gene by activated
Notch was mediated by increased binding of p53 to p53 binding sites in the p21 ( cip/waf ) promoter and was independent of the canonical RBP-J binding site
Heo et al., Growth Factors 2008
:
Moreover, TGF-alpha increased cyclin D/CDK 4 and cyclin E/CDK 2 levels, while decreasing
p21cip1/waf1 and p27kip1, which were
blocked by the inhibition of Akt, mTOR and
Notch
Garg et al., Gastroenterology 2011
(Colitis...) :
Inhibition of
Notch1 signaling significantly
reduced protein levels of active Notch1, p53,
p21WAF1/Cip1 , Bax-1, active caspase-3, as well as apoptosis, compared with controls
Cui et al., Cancer Res 2013
(Neoplasms) :
The ability of Notch3 to induce senescence and
p21 expression was
dependent on the canonical
Notch singling