◀ Back to HIF1A
BCL2 — HIF1A
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ikeda et al., Biochem Biophys Res Commun 2002
:
Thus 2-deoxy-D-ribose modulated suppression of
HIF-1 alpha expression could
prevent the hypoxia induced decrease of the anti-apoptotic
Bcl-2 and Bcl-x ( L ) on the mitochondria
Kilic et al., Oncogene 2007
(Anoxia) :
Concomitant analysis of antiapoptotic proteins revealed that hypoxia induced expression of
Bcl-2 and inhibitor of apoptosis proteins (IAP)-2 as well as proteins associated with anaerobic metabolism such as the glucose transporter protein GLUT-1 and the glycolytic enzyme Aldolase A. Specific downregulation of
Hif-1alpha by RNA interference significantly
enhanced apoptosis under hypoxia by preventing the hypoxia mediated increase in GLUT-1 expression without altering expression levels of the antiapoptotic proteins Bcl-2 or cIAP-2
Yang et al., Transplantation 2009
(Anoxia...) :
RHP increased renal HIF-1 alpha mRNA and protein expression and triggered
HIF-1 alpha dependent renal
Bcl-2 protein expression in a time dependent manner
Menrad et al., Hepatology 2010
(Carcinoma, Hepatocellular...) :
Furthermore, an HIF-2alpha-knockdown significantly increased
Bcl-2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) expression in an
HIF-1alpha dependent manner