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FGF19 — FGF8

Pathways - manually collected, often from reviews:

• Reactome Reaction: FGF8 → FGF19 (reaction) Carpenter et al., Exp Cell Res 1999, Hart et al., Mol Biol Cell 2001, Wong et al., Proc Natl Acad Sci U S A 2002, Lax et al., Mol Cell 2002, Fong et al., J Biol Chem 2003, Mohammadi et al., Nature 1992, Agazie et al., Oncogene 2003, Mohammadi et al., Mol Cell Biol 1991, Ahmed et al., Biochem J 2008, Schüller et al., Biochem J 2008, Klint et al., J Biol Chem 1995, Wang et al., Mol Cell Biol 1994, Mohammadi et al., Mol Cell Biol 1996, Ong et al., Biochem Biophys Res Commun 1996, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998

Text-mined interactions from Literome

Liu et al., Development 2002 (Limb Deformities, Congenital) : In this system, FGF10 but not FGF8 protein injected into the mutant distal tip mesenchyme restores Fgf8 expression in the AER
Ladher et al., Genes Dev 2005 : We show that endoderm is necessary for otic induction in the chick and that Fgf8 , expressed in the chick endoderm subjacent to Fgf19, is both sufficient and necessary for the expression of Fgf19 in the mesoderm
Saitsu et al., Mech Dev 2006 (Heart Defects, Congenital) : Moreover, over-expression of Fgf15 resulted in up-regulation of Fgf8 expression in the isthmus/r1
Kurosu et al., J Biol Chem 2007 : Accordingly, FGF19 , but not FGF21, activates FGF signaling in hepatocytes that primarily express FGFR4 and reduces transcription of CYP7A1 that encodes the rate limiting enzyme for bile acid synthesis
Katayama et al., Int J Oncol 2010 (Prostatic Neoplasms) : Overall, bicalutamide inhibits the cyclin A expression possibly by inhibiting FGF-8 mRNA expression and FGF-8 protein secretion but not by inhibiting FGF receptor ( FGFR ) signalling in androgen dependent cell lines, and by other mechanisms in androgen independent cell lines