Lu et al., J Biol Chem 2003
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Although inhibition of histone deacetylase activity results in an increase of CREB- or CBP mediated gene expression, mutation of all three putative acetylation sites in the CREB activation domain markedly enhances the ability of CREB to activate a cAMP-responsive element dependent reporter gene
Gao et al., Biochem Biophys Res Commun 2009
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Expression of recombinant HDAC8 results in decreased CREB activation and CREB mediated gene transcription in response to forskolin application