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EGFR — PLAUR
Text-mined interactions from Literome
Liu et al., Cancer Cell 2002
(Carcinoma, Hepatocellular...) :
Its activation is ligand independent and does not
require high
EGFR , but does require high
uPAR expression
Mamoune et al., Exp Cell Res 2004
(Carcinoma...) :
Gene microarray analyses have suggested that
EGFR signaling via phospholipase C-gamma ( PLCgamma )
induces uPAR transcription
Monaghan-Benson et al., J Biol Chem 2006
:
The effects of P25 on matrix assembly and beta1 integrin activation were inhibited by pretreatment with EGFR or Src kinase inhibitors, suggesting a
role for both Src and
EGFR in integrin activation by
uPAR ... These data provide evidence for a novel pathway of fibronectin matrix assembly through the
uPAR dependent sequential activation of Src kinase,
EGFR , and beta1 integrin
Gondi et al., Clin Cancer Res 2007
(Brain Neoplasms...) :
In 4910 EGFR overexpressing cells, down-regulation of
uPAR and uPA
induced the down-regulation of
EGFR and vascular endothelial growth factor and inhibited angiogenesis in both in vitro and in vivo angiogenic assays
Abu-Ali et al., Molecular cancer 2008
(Head and Neck Neoplasms) :
ACCS, ACCS-AS and NA-SCC cells were used to elucidate the relationships between
uPAR down-regulation and
EGFR inhibition
Monaghan-Benson et al., J Cell Sci 2008
:
Caveolin-1 functions initially as a membrane adaptor or scaffold to mediate
uPAR dependent
activation of Src and
EGFR