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FGF2 — FGFBP1
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
FGF2
—
FGFBP1
(coimmunoprecipitation)
Beer et al., Oncogene 2005*
-
IRef Biogrid Interaction:
FGF2
—
FGFBP1
(direct interaction, pull down)
Tassi et al., J Biol Chem 2001*
-
IRef Hprd Interaction:
FGF2
—
FGFBP1
(in vivo)
Tassi et al., J Biol Chem 2001*
-
IRef Intact Interaction:
FGF2
—
FGFBP1
(direct interaction, t7 phage display)
Xie et al., J Biol Chem 2006*
-
IRef Intact Interaction:
FGF2
—
FGFBP1
(direct interaction, surface plasmon resonance)
Xie et al., J Biol Chem 2006*
-
IRef Intact Interaction:
FGF2
—
FGFBP1
(direct interaction, competition binding)
Xie et al., J Biol Chem 2006*
-
IRef Ophid Interaction:
FGF2
—
FGFBP1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Aigner et al., Int J Cancer 2001
(Adrenal Gland Neoplasms...) :
Since previous studies provided only indirect evidence for the proposed mechanism of
FGF-BP mediated
FGF-2 release, we decided to use recombinant purified FGF-BP to study further the underlying mechanism of FGF-BP action
Beer et al., Oncogene 2005
:
The
fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and
regulates FGF activity : implications for epithelial repair ... The
fibroblast growth factor binding protein ( FGF-BP ) binds and
activates FGF-1 and
FGF-2 , thereby contributing to tumor angiogenesis
Tassi et al., Am J Physiol Regul Integr Comp Physiol 2007
(Spinal Cord Injuries) :
Moreover, using PC12 cells as a neuronal model, we observed that exogenous
FGF-BP increased the capacity of
FGF2 to stimulate neurite outgrowth and to increase cell survival
Newman et al., Am J Physiol Lung Cell Mol Physiol 2007
:
Functionally,
FGF-BP shuttles FGFs from binding sites in ECMs to cell surfaces and
enhances FGF binding and signaling, whereas NDST-1 adds sulfate groups to FGF coreceptor proteoglycans and modulates alveolar type II ( ATII ) cell maturation and differentiation
Wu et al., J Biol Chem 1991
:
In addition
HBp17 was found to
inhibit the biological activities of both HBGF-1 and
HBGF-2
Kurtz et al., Oncogene 1997
(Skin Neoplasms) :
Recently, we have shown that a novel human
FGF binding protein (FGF-BP) mediates the release of immobilized
FGF-2 from the EM
Czubayko et al., Nat Med 1997
(Carcinoma, Squamous Cell...) :
We found that the reduction of
FGF-BP reduced the release of biologically active
basic FGF (bFGF) from cells in culture