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FGF2 — KDR
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
KDR
→
FGF2
(increases)
Evidence: Both low and high MW FGF-2 isoforms show angiogenic activity in vivo and induce cell proliferation, chemotaxis, and uPA production in cultured endothelial cells (188). Also, FGF-2 was found to induce tube formation in collagen gels and to modulate integrin expression, gap junction intercellular communication and VEGF, Flk-1 and uPAR upregulation in vitro (31, 100).
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WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway:
EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16
→
FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK
(activation)
Text-mined interactions from Literome
Hata et al., Diabetes 1999
:
Basic fibroblast growth factor induces expression of VEGF receptor
KDR through a protein kinase C and p44/p42 mitogen activated protein kinase dependent pathway ... We examined whether VEGF and
bFGF affect expression of each other or alter expression of the VEGF receptor
KDR in retinal capillary endothelial cells
Ishibashi et al., Nihon Ganka Gakkai Zasshi 1999
(Diabetic Retinopathy...) :
AGEs and
basic fibroblast growth factor (bFGF) induced expression of
KDR in REC, and a transcription factor Sp 1 was involved in this process
Liu et al., Arterioscler Thromb Vasc Biol 2003
:
VEGF induced NR4A family and Egr3 expression was blocked by a
KDR inhibitor, and placental growth factor and
basic fibroblast growth factor weakly
increased expression of these genes
Xiao et al., Cell Res 2007
:
Upregulation of
Flk-1 by
bFGF via the ERK pathway is essential for VEGF mediated promotion of neural stem cell proliferation
Ren et al., Blood 2011
:
LPA induced MVEC CD36 repression significantly attenuated in vitro antiangiogenic responses to thrombospondin-1, including blockade of migration, tube formation, and
VEGFR-2 signaling in
response to
fibroblast growth factor-2
Murakami et al., J Clin Invest 2011
(Ischemia) :
FGF mediated
VEGFR2 expression via activation of Erk1/2
Chamorro-Jorganes et al., Arterioscler Thromb Vasc Biol 2011
:
Reduced expression of
VEGFR2 and FGFR1 by miR-16 or miR-424 overexpression
regulated VEGF and
bFGF signaling through these receptors, thereby affecting the activity of downstream components of the pathways
Santos et al., Tissue Eng Part A 2013
:
Additionally, the release of VEGF and
FGF-2 from the constructs
enhanced the expression of
VEGFR2 and other important mediators in neovascularization ( VEGF and VEGFR1 )