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CCND1 — FGF2

Text-mined interactions from Literome

Jones et al., Endocrinology 2000 : Taken together, these results show that progesterone-FGF interactions increase cyclin D1 expression, correlating with accelerated stromal cell entry into S phase compared with cells treated with FGF alone
Lotfi et al., Endocr Res 2000 (Adrenal Cortex Neoplasms) : But, the MEK1 inhibitor, PD98059 ( 50microM ), inhibits cFos and cyclin D1 induction and DNA synthesis stimulation by both ACTH39 and FGF2 , suggesting that ERK1/2 activation mediates the strong and the weak mitogenic effect of, respectively, FGF2 and ACTH39
Frederick et al., Mol Cell Neurosci 2004 : IGF-I and FGF-2 coordinately enhance cyclin D1 and cyclin E-cdk2 association and activity to promote G1 progression in oligodendrocyte progenitor cells ... IGF-I enhanced FGF-2 induction of cyclin D1 , activation of G ( 1 ) cyclin-cyclin dependent kinase (cdk) complexes, and hyperphosphorylation of retinoblastoma protein ( pRb )
Kalluri et al., Eur J Neurosci 2007 : Accordingly, stimulation of the ERK pathway by FGF-2 induced the expression of cyclin D1 , which is essential for the entry of cells into cell cycle, and IGF-I in the presence of FGF-2 up-regulated the expression of cyclin D1
Frederick et al., Glia 2007 (MAP Kinase Signaling System) : Synergistic induction of cyclin D1 in oligodendrocyte progenitor cells by IGF-I and FGF-2 requires differential stimulation of multiple signaling pathways ... Thus, we provide a model for cyclin D1 coordinate regulation where FGF-2 stimulation of the MAPK pathway promotes cyclin D1 mRNA expression while IGF-I activation of the PI3K pathway inhibits proteasome degradation of cyclin D1 and enhances nuclear localization of cyclin D1
Neary et al., Purinergic Signal 2005 : We found that ATP potentiated the ability of FGF2 to stimulate expression of cyclin D1 , a regulator of cell cycle entry, as well as cyclin A, a regulator of DNA replication
Nilsson et al., Exp Cell Res 2010 (Breast Neoplasms) : In S115 and MCF-7 mouse tumours, FGF-8b increased cyclin D1 and Ki67 levels
Sakai et al., Biochem Biophys Res Commun 2010 : Basic fibroblast growth factor (bFGF) induced ERK phosphorylation and cyclin D1 expression were unchanged by perlecan deficiency in endothelial cells ; however, perlecan deficiency inhibited the Rb protein phosphorylation and DNA synthesis induced by bFGF
Rao et al., J Biol Chem 1995 : Expression of cyclin D1 was induced in myoblasts by bFGF and TGF beta ( albeit with different kinetics for each factor ), while induction of cyclin D3 expression was inhibited by these growth factors
Wang et al., Cancer Res 1997 : bFGF induced an increase in cyclin D1 , cyclin E, and cyclin dependent kinase 4 (cdk4) protein levels in a bFGF dose dependent manner
Boudreau et al., J Cell Biol 1997 (Hemangioendothelioma...) : Hox D3 antisense blocked the ability of bFGF to induce uPA and integrin alphavbeta3 expression, yet had no effect on EC cell proliferation or bFGF mediated cyclin D1 expression