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CX3CR1 — TNF

Text-mined interactions from Literome

Croitoru-Lamoury et al., Glia 2003 : Moreover, TNFalpha and IL-1beta significantly increase BOB/GPR15, CCR2, and V28/CX3CR1 mRNA levels in both models
Chandrasekar et al., Biochem J 2003 : TNF-alpha activated nuclear factor kappaB (NF-kappaB) and induced fractalkine and CX3CR1 expression in a time dependent manner in rat aortic SMCs. Transient transfections with dominant negative ( dn ) inhibitory kappaB (IkappaB)-alpha, dnIkappaB-beta, dnIkappaB kinase ( IKK)-gamma, kinase-dead ( kd ) NF-kappaB inducing kinase (NIK) and kdIKK-beta, or pretreatment with wortmannin, Akt inhibitor, pyrrolidinecarbodithioc acid ammonium salt ( ` PDTC ' ) or MG-132, significantly attenuated TNF-alpha induced fractalkine and CX3CR1 expression ... Taken together, our results demonstrate that TNF-alpha induces the expression of fractalkine and CX3CR1 in rat aortic SMCs and that this induction is mediated by NF-kappaB activation
Yano et al., Acta Med Okayama 2007 (Arthritis, Rheumatoid...) : In the in vitro culture experiments, IL-10 induced CX3CR1 expression on the surface of monocytes, and TNFalpha induced membrane bound FKN as well as soluble FKN expression in synovial fibroblasts
Mizutani et al., J Immunol 2007 : In contrast, pretreatment with 3 nM FKN induced higher levels of IL-23 compared with cells pretreated with 0.03 nM FKN and produced TNF-alpha in a CX3CR1 dependent manner
Sung et al., Cell Physiol Biochem 2010 : Genistein also strongly suppressed TNF-alpha induced expression of CX3CR1 in monocytes
Xiong et al., J Immunol 2011 (Pulmonary Emphysema) : Rather, functional CX3CR1 was required for a subset of tissue bound mononuclear phagocytes to produce TNF-a and IL-6 in response to cigarette smoke, and the absence of functional CX3CR1 protected mice from developing tissue-destructive emphysema