◀ Back to NOTCH4

IL10 — NOTCH4

Text-mined interactions from Literome

Benson et al., Eur J Immunol 2005 : Notch1 co-localizes with CD4 on activated T cells and Notch signaling is required for IL-10 production ... In addition, the finding that Notch signaling is required for production of IL-10 may allude to a role in immune regulation
Rutz et al., Proc Natl Acad Sci U S A 2008 (Hypersensitivity, Delayed) : Notch regulates IL-10 production by T helper 1 cells ... Here, we show that Notch induces IL-10 production in newly developing and already established Th1 cells via a signal transducer and activator of transcription 4 ( STAT4 ) -dependent process ... Our data suggest that Notch regulates IL-10 production in Th1 cells by a STAT4 dependent process that converts proinflammatory Th1 cells into T cells with regulatory activity