Gene interactions and pathways from curated databases and text-mining

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MAPK4 — SIRT1

Text-mined interactions from Literome

Ota et al., Oncogene 2006 (Breast Neoplasms...) : Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
Seo et al., Neurobiol Aging 2012 : SIRT1 activation also inhibited PrP ( 106-126 ) -mediated p38 mitogen activating protein kinase ( MAPK ) activation and caspase-3 cleavage, and increased the expression of anti-apoptotic Bcl-xL protein
Park et al., J Periodontal Res 2013 : Resveratrol and Ad-SIRT1 decreased LPS and nicotine induced cytotoxicity, ROS and PGE2 production, and expression of cyclooxygenase-2 in HGFs. Resveratrol and Ad-SIRT1 inhibited nicotine and LPS mediated protein kinase C ( PKC ), phosphatidylinositol 3-kinase (PI3K), p38, ERK, JNK, MAPK and nuclear factor-kappa B ( NF-?B ) activation