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MAPKAPK2 — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Neininger et al., J Biol Chem 2002
:
MK2 targets AU-rich elements and
regulates biosynthesis of
tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
Chrestensen et al., J Biol Chem 2004
:
MAPKAP kinase 2 (MK2) is
required for
tumor necrosis factor synthesis
Johansen et al., J Immunol 2006
(Psoriasis) :
Protein expression of
TNF-alpha in psoriatic skin is
regulated at a posttranscriptional level by
MAPK activated protein kinase 2 ... The results strongly suggest that increased activation of
MK2 is responsible for the elevated and posttranscriptionally
regulated TNF-alpha protein expression in psoriatic skin, making MK2 a potential target in the treatment of psoriasis
Kervinen et al., Arch Biochem Biophys 2006
:
MAPK activated protein kinase-2 ( MAPKAPK2 )
regulates the synthesis of
tumor necrosis factor and other cytokines and is a potential drug target for inflammatory diseases
Hegen et al., J Immunol 2006
(Arthritis, Experimental) :
We show that
MK2 ( -/- ) and MK2 ( +/- ) mice exhibit decreased disease incidence and severity in the CIA disease model and
reduced TNF-alpha and IL-6 serum levels following LPS/d-Gal treatment compared with wild-type mice
Thuraisingam et al., Mol Immunol 2007
:
Distinct
role of
MAPKAPK-2 in the regulation of
TNF gene expression by Toll-like receptor 7 and 9 ligands
Su et al., Biochim Biophys Acta 2008
(MAP Kinase Signaling System) :
TNF stimulation
induced p38 MAPK dependent phosphorylation of
MK2 and HSP27
Duraisamy et al., Expert Opin Ther Targets 2008
(Inflammation) :
Disruption of
MK2 leads to a reduction in
TNF-alpha production
Matsumiya et al., J Immunol 2010
:
TNF-alpha treatment resulted in the phosphorylation of p38 MAPK and its downstream target, MAPK activated protein kinase-2, but IFN-gamma did not affect the levels of MAPK and
MAPK activated protein kinase-2 phosphorylation
induced by
TNF-alpha
Engel et al., J Cell Biochem 1995
(Carcinoma, Ehrlich Tumor...) :
MAPKAP kinase 2 is
activated by heat shock and
TNF-alpha : in vivo phosphorylation of small heat shock protein results from stimulation of the MAP kinase cascade
Beyaert et al., EMBO J 1996
:
Pretreatment of cells with the highly specific p38 MAP kinase inhibitor SB203580 completely blocked this
TNF induced
activation of
MAPKAP kinase-2 and hsp27 phosphorylation
Laird et al., Cell Signal 1998
:
TNF stimulated activation of p38 MAP kinase, and
MAPKAP kinase-2 , a known downstream target of p38 MAP kinase, was strongly inhibited by pre-incubation with the p38 MAP kinase inhibitor SB203580, whereas the minor activation of p42/44 MAP kinase was abolished by pre-incubation of the cell with the novel MAP kinase kinase 1 inhibitor PD098059
Schafer et al., J Immunol 1999
:
SB 203580, a selective inhibitor of p38, blocked p38 and
MAPKAPK-2 activation in the T cell clone but did not completely
inhibit TNF-alpha release