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BIRC3 — CASP14
Text-mined interactions from Literome
Partheniou et al., Biochem Biophys Res Commun 2001
(Leukemia) :
In contrast, there was a
caspase dependent cleavage of XIAP, but not
c-IAP1 , during treatment with TNFalpha for 7 days
Mica et al., J Am Coll Surg 2004
(Sepsis) :
Endotoxin reduces CD95 induced neutrophil apoptosis by
cIAP-2 mediated
caspase-3 degradation
Levkovitch-Verbin et al., Invest Ophthalmol Vis Sci 2006
(Disease Models, Animal...) :
Proapoptotic genes from the p-53 pathway ( Ei24 and Gadd45a ), Cdk2 and the prosurvival gene
IAP-1 ( a
caspase inhibitor ) were simultaneously and significantly upregulated early after ONT, returning to baseline at 2 weeks
Igaki et al., Biochem Biophys Res Commun 2007
:
DmHtrA2 specifically cleaves Drosophila
inhibitor-of-apoptosis protein 1 ( DIAP1 ), a cellular
caspase inhibitor , and induces cell death both in vitro and in vivo as potent as other fly cell death proteins
Das et al., Cancer 2007
(Glioblastoma) :
Other events in apoptosis included overexpression of Bax, down-regulation of Bcl-2 and some
BIRC proteins, mitochondrial release of cytochrome c and Smac into the cytosol, and
activation of calpain,
caspase-9 , and caspase-3
Das et al., Brain Res 2008
(Brain Neoplasms...) :
Besides, apoptosis was associated with alterations in expression of pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins resulting in an increase in Bax : Bcl-2 ratio, mitochondrial release of cytochrome c and Smac, downregulation of selective baculoviral inhibitor-of-apoptosis repeat containing (
BIRC ) molecules, an increase in intracellular free [Ca2+ ], and
activation of calpain and
caspase-3
Karmakar et al., Neuroscience 2009
(Body Weight...) :
Combination of 4-HPR and GST increased Bax : Bcl-2 ratio, mitochondrial release of Smac, downregulation of baculovirus inhibitor-of-apoptosis repeat containing (
BIRC ) proteins including BIRC-2 and BIRC-3, and activation of
caspase-3 and apoptosis
inducing factor ( AIF )