◀ Back to PXN
PXN — VCL
Pathways - manually collected, often from reviews:
-
BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia:
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1)
→
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
(actin filament polymerization, collaborate)
-
BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia:
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
→
PIP2/Gelsolin complex (GSN)
(actin filament polymerization, collaborate)
-
BioCarta integrin signaling pathway:
None
→
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
Zyxin (ZYX)
→
ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
Zyxin (ZYX)
→
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
CSK
→
ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
CSK
→
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1)
→
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1)
→
Tensin (TNS1)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1)
→
FAK (PTK2)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1)
→
NOLC1
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1)
→
Calpain1 (CAPN1)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1)
→
Actin (ACTA1)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1)
→
alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
→
Tensin (TNS1)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
→
FAK (PTK2)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
→
NOLC1
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
→
Calpain1 (CAPN1)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
→
Actin (ACTA1)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
→
alpha-actinin (ACTN3/ACTN2/ACTN1/ACTN4)
(modification, collaborate)
-
BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia:
Rho-Kinase Dia/Profilin complex (PFN1-DIAPH1)
→
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1)
(actin filament polymerization, activates)
-
BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia:
Rho-Kinase Dia/Profilin complex (PFN1-DIAPH1)
→
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
(actin filament polymerization, activates)
-
BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia:
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1)
→
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
(actin filament polymerization, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1)
→
Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-TLN1-ITGB1)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-ITGB1-TLN1)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
Integrin-alpha/Integrin-beta/Talin/Paxillin/Vinculin complex (VCL-PXN-ITGA1-TLN1-ITGB1)
(modification, collaborate)
-
BioCarta integrin signaling pathway:
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1)
→
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
(actin filament polymerization, collaborate)
-
Reactome Reaction:
PXN
→
VCL
(direct_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
PXN
—
VCL
(direct interaction, pull down)
Turner et al., J Cell Biol 1999
-
IRef Biogrid Interaction:
PXN
—
VCL
(direct interaction, pull down)
Mazaki et al., J Biol Chem 1997*
-
IRef Biogrid Interaction:
PXN
—
VCL
(direct interaction, pull down)
Brown et al., J Cell Biol 1996
-
MIPS CORUM Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1):
Polycystin-1 multiprotein complex (ACTN1, CDH1, SRC, JUP, VCL, CTNNB1, PXN, BCAR1, PKD1, PTK2, TLN1) complex (ACTN1-BCAR1-CDH1-CTNNB1-JUP-PKD1-PTK2-PXN-SRC-TLN1-VCL)
Geng et al., Biochim Biophys Acta 2000
-
IRef Corum Interaction:
Complex of 12 proteins
(association, cosedimentation through density gradient)
Geng et al., Biochim Biophys Acta 2000
-
IRef Dip Interaction:
Complex of PXN-PXN-VCL-VCL-NDEL1-NDEL1
(anti tag coimmunoprecipitation)
Shan et al., PLoS Biol 2009*
-
IRef Hprd Interaction:
PXN
—
VCL
(in vivo)
Turner et al., J Cell Sci 1994*, Salgia et al., J Biol Chem 1995*, Mazaki et al., J Biol Chem 1997*
-
IRef Hprd Interaction:
PXN
—
VCL
(in vitro)
Turner et al., J Cell Sci 1994*, Salgia et al., J Biol Chem 1995*, Mazaki et al., J Biol Chem 1997*
-
IRef Intact Interaction:
VCL
—
PXN
(colocalization, fluorescence microscopy)
Pasapera et al., J Cell Biol 2010
-
IRef Ophid Interaction:
VCL
—
PXN
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Tang et al., J Physiol 2002
:
Paxillin antisense selectively depressed paxillin expression, but it did not
affect the expression of
vinculin , focal adhesion kinase, myosin light chain kinase, myosin heavy chain or myosin light chain
Melendez et al., J Biol Chem 2004
:
Wild-type or mutant
paxillin protein accumulation in the cytoplasm has no overt effect upon cell structure, but paxillin accumulation
prevents losses of myofibril organization as well as focal adhesion kinase,
vinculin , and paxillin protein levels mediated by RAFTK
Brown et al., J Mol Biol 2011
(HIV Infections) :
Together, these findings demonstrate that talin-1 and
vinculin negatively
affect tyrosine phosphorylation of
paxillin , a novel positive regulator of HIV-1 infection, and impose an early block to infection by distinct retroviruses