◀ Back to TLR2
AKT3 — TLR2
Text-mined interactions from Literome
Miller et al., Arterioscler Thromb Vasc Biol 2005
(Atherosclerosis) :
In turn,
TLR4 regulated phosphorylation of ERK1/2 but not of
Akt , suggesting that mmLDL induced PI3K activation is TLR4 independent
Lentschat et al., J Immunol 2005
:
In addition to inhibition of TLR4 mediated MAPK phosphorylation in macrophages, mastoparan blunted IL-1R associated kinase-1 kinase activity induced by LPS, but not by TLR2 agonists, yet failed to affect phosphorylation of
Akt by phosphoinositol-3-kinase
induced by either
TLR2- or TLR4 mediated signaling
Yang et al., Cell Microbiol 2006
(MAP Kinase Signaling System) :
To extend these studies, we examined the nature of the involvement of toll-like receptors ( TLRs ) and intracellular signalling pathways downstream from PI3K in M. tbc induced IL-23 expression in human MDMs. M. tbc
induced Akt activation and IL-23 expression were essentially dependent on
TLR2
Pathak et al., Nat Immunol 2007
:
Direct binding of ESAT-6 to
TLR2 activated
Akt and prevented interaction between the adaptor MyD88 and ` downstream ' kinase IRAK4, thus abrogating NF-kappaB activation
Quigley et al., Blood 2009
(Vaccinia) :
Furthermore, we observed that direct
TLR2 ligation on CD8 T cells promoted CD8 T-cell proliferation and survival in vitro in a manner dependent on the phosphatidylinositol 3-kinase (PI3K)-Akt pathway activation and that activation of
Akt controlled memory cell formation in vivo
Santos-Sierra et al., EMBO J 2009
:
In contrast to TLR2/6,
TLR2/1 does not
require Mal or MyD88 for
Akt phosphorylation ... In contrast to TLR2/6,
TLR2/1 does not
require Mal or MyD88 for
Akt phosphorylation
Wagner et al., Arterioscler Thromb Vasc Biol 2013
(Ischemia...) :
The effects of anti-TLR2 ABs were similar to those exerted by stromal cell derived factor-1, and we show that anti-TLR2 ABs yet not
TLR2 ligands
lead to comparable activation of extracellular signal regulated kinase1/2 and
AKT but not p38 mitogen activated protein kinase as activation of the CXCR4 canonical signal transduction pathways by stromal cell derived factor-1