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AR — STAT3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: AR → STAT3 (directlyIncreases, STAT3 Activity, AR Activity) Ueda et al., J Biol Chem 2002*
  Evidence: Immunoprecipitation and transactivation studies showed a direct interaction between amino acids 234-558 of the AR NTD and STAT3 following IL-6 treatment of LNCaP cells. These results demonstrate that activation of the human AR NTD by IL-6 was mediated through MAPK and STAT3 signal transduction pathways in LNCaP prostate cancer cells.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: STAT3 — AR (physical association, affinity chromatography technology) Yamamoto et al., Biochem Biophys Res Commun 2003*
• IRef Biogrid Interaction: STAT3 — AR (physical association, affinity chromatography technology) Matsuda et al., Biochem Biophys Res Commun 2001*
• IRef Biogrid Interaction: STAT3 — AR (direct interaction, pull down) Ueda et al., J Biol Chem 2002*
• IRef Hprd Interaction: AR — STAT3 (in vivo) Ueda et al., J Biol Chem 2002*, Yamamoto et al., Biochem Biophys Res Commun 2003*
• IRef Hprd Interaction: AR — STAT3 (in vitro) Ueda et al., J Biol Chem 2002*, Yamamoto et al., Biochem Biophys Res Commun 2003*
• IRef Ophid Interaction: AR — STAT3 (aggregation, confirmational text mining) Ueda et al., J Biol Chem 2002*
• IRef Ophid Interaction: AR — STAT3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005