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THBD — TNF
Text-mined interactions from Literome
Murugesan et al., J Biomed Mater Res 2000
:
Endothelial cells ( EC ) from human aortas, microvessels, and pulmonary arteries were examined for their expression and activity of monocyte chemotactic protein-1 (MCP-1), tissue factor, and
thrombomodulin in
response to
tumor necrosis factor-alpha (TNFalpha) on the hydrophilic plasma polymers gamma-butyrolactone ( GBL ) and N-vinyl-2-pyrrolidone ( NVP ), along with a fibronectin ( FN ) control ... Basal expression of thrombomodulin was largely comparable for all three cell types grown on different surfaces, but
TNFalpha suppressed
thrombomodulin to different extents depending on the origin of the EC
Nan et al., Thromb Res 2005
:
The objective of this study was to elucidate the
effects of
tumor necrosis factor-alpha (TNF-alpha) on the expression of
thrombomodulin (TM) and endothelial protein C receptor ( EPCR ) in human endothelial cells as well as the effect of curcumin, a spice and coloring food compound, as a potential therapeutic agent
Dekker et al., Blood 2006
:
Protein levels for
thrombomodulin , endothelial nitric oxide synthase, and plasminogen activator inhibitor type-1 are altered to atheroprotective levels, even in the
presence of the inflammatory cytokine
TNF-alpha
Ohdama et al., Thromb Res 1991
:
Pentoxifylline prevents
tumor necrosis factor induced suppression of endothelial cell surface
thrombomodulin
Schmidt et al., Ann Thorac Surg 2006
:
Stimulation with
tumor necrosis factor-alpha resulted in physiologic upregulation of tissue factor and downregulation of
thrombomodulin expression
Maruyama et al., Thromb Res 1991
(Hemangioma) :
These agents prevented the interleukin I (IL-I) or
tumor necrosis factor (TNF) induced decrease in
thrombomodulin on HUVEC
Soff et al., Blood 1991
:
Expression of thrombomodulin by smooth muscle cells in culture : different
effects of
tumor necrosis factor and cyclic adenosine monophosphate on
thrombomodulin expression by endothelial cells and smooth muscle cells in culture
Lentz et al., Blood 1991
:
Regulation of
thrombomodulin by
tumor necrosis factor-alpha : comparison of transcriptional and posttranscriptional mechanisms ... We conclude that
TNF acts primarily to
inhibit thrombomodulin transcription
Hirokawa et al., J Biochem 1990
:
Previous studies have shown that
thrombomodulin (TM) on endothelial cells is
down-regulated by endotoxin, interleukin-1 beta (IL-1 beta), and
tumor necrosis factor (TNF)
Stern et al., Diabetes Care 1991
:
Tumor necrosis factor suppresses the endothelial anticoagulant cofactor
thrombomodulin and induces expression of the procoagulant cofactor tissue factor
Scarpati et al., J Biol Chem 1989
:
In contrast to PMA,
TNF reduced
thrombomodulin activity approximately 80 % with no change in thrombomodulin mRNA levels ... The different
effects of PMA and
TNF on
thrombomodulin expression indicate that some effects of TNF are not mediated solely by protein kinase C
Conway et al., Mol Cell Biol 1988
:
Tumor necrosis factor suppresses transcription of the
thrombomodulin gene in endothelial cells
Herbert et al., FEBS Lett 1993
:
When measured in parallel, IL-4 and IL-13 counteracted
thrombomodulin down-regulation
induced by LPS, IL-1 or
TNF in endothelial cells
Herbert et al., Thromb Res 1993
:
Endotoxin, interleukin 1 beta (IL-1 beta) and
tumor necrosis factor alpha (TNF-alpha) dose-dependently increased the expression of tissue factor and at the same time
induced thrombomodulin down-regulation on the surface of cultured bovine aortic endothelial cells
Endo et al., Res Commun Mol Pathol Pharmacol 1995
(Disseminated Intravascular Coagulation...) :
TNF-alpha is
involved in the production of endothelin-1 and
thrombomodulin , which play a role in the pathogenesis of DIC and whose blood levels reflect its severity
Raife et al., Blood 1996
:
Thrombomodulin expression in endothelial cells is
regulated by retinoic acid and
tumor necrosis factor-alpha (TNF) , agents that also modulate epidermal differentiation ... We examined
thrombomodulin function and
regulation of thrombomodulin expression by all-trans retinoic acid ( ATRA ) and
TNF in human keratinocytes and endothelial cells ... These results demonstrate that keratinocyte
thrombomodulin is
regulated by retinoids and Ca2+, but not by
TNF , and that regulation of thrombomodulin expression differs in keratinocytes and endothelial cells
Kopp et al., Transplantation 1998
:
Our aim was to express human TM cofactor activity in PAEC and to study the proinflammatory
effect of
tumor necrosis factor-alpha (TNF-alpha) on stable expressed human
thrombomodulin in vitro