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CCND1 — CCND3

Pathways - manually collected, often from reviews:

• KEGG Cell cycle: CDKN1B/CDKN1C → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN1A → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: PCNA → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN2B → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: Complex of CCND1-CCND2-CCND3-CDK4-CDK6 → RBL1/RBL2 (protein-protein, inhibition)
• KEGG Cell cycle: Complex of CCND1-CCND2-CCND3-CDK4-CDK6 → RB1 (protein-protein, inhibition)
• KEGG Cell cycle: CDKN2A → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN2C → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG Cell cycle: CDKN2D → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• KEGG p53 signaling pathway: CDKN1A → Complex of CCND1-CCND2-CCND3-CDK4-CDK6 (protein-protein, inhibition)
  
• NCI Pathway Database Regulation of retinoblastoma protein: CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, inhibits)
  Zhang et al., Cell 2000, Rubin et al., Cell 2005, Kato et al., Genes Dev 1993, Fåhraeus et al., Curr Biol 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Regulation of retinoblastoma protein: CDK4-6/Cyclin D/p16INK4a complex (CDK6_CDK4-CCND3_CCND2_CCND1-CDKN2A) → CDK4-6/Cyclin D complex (CDK6_CDK4-CCND3_CCND2_CCND1) (modification, collaborate)
  Fåhraeus et al., Curr Biol 1996
  Evidence: physical interaction
• WikiPathways Wnt Signaling Pathway and Pluripotency: EP300 → Complex of 11 proteins (activation)
• WikiPathways Wnt Signaling Pathway and Pluripotency: ZBTB33 → Complex of 11 proteins (mim-inhibition)
• WikiPathways miRNA Regulation of DNA Damage Response: Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 → Complex of CDK2-CCNE2-CCNE1 (inhibition)
  
• WikiPathways miRNA Regulation of DNA Damage Response: CDC25A → Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 (activation)
  
• WikiPathways DNA Damage Response: Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 → Complex of CDK2-CCNE2-CCNE1 (inhibition)
  
• WikiPathways DNA Damage Response: CDC25A → Complex of CDK4-CCND1-CDK6-CCND2-CCND3-CDK5 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM Cell cycle kinase complex CDK5: Cell cycle kinase complex CDK5 complex (CCND1-CCND3-CDK5-CDKN1A-PCNA) Zhang et al., Mol Biol Cell 1993
• IRef Corum Interaction: Complex of CCND1-PCNA-CCND3-CDK5-CDKN1A (association, anti bait coimmunoprecipitation) Zhang et al., Mol Biol Cell 1993
• IRef Intact Interaction: Complex of CCND3-CDK6-CCND1 (association, anti bait coimmunoprecipitation) Shu et al., Proc Natl Acad Sci U S A 2007*

Text-mined interactions from Literome

Freemantle et al., Int J Oncol 2007 (Neoplasms, Germ Cell and Embryonal) : Notably, GCT differentiation was associated with reduced cyclin D1 but increased cyclin D3 expression
Rao et al., J Biol Chem 1995 : Expression of cyclin D1 was induced in myoblasts by bFGF and TGF beta ( albeit with different kinetics for each factor ), while induction of cyclin D3 expression was inhibited by these growth factors