Patke et al., Curr Opin Immunol 2004
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BCR signaling leads to activation of the inhibitor of NF-kappa B kinase (IKK) complex via Carma1, Bcl10 and MALT1, whereas BAFF-R engagement promotes processing of NF-kappa B2 protein p100, which is dependent on NF-kappa B-inducing kinase (NIK) and IKK alpha
Shinohara et al., J Exp Med 2007
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We show that PKCbeta mediates phosphorylation of CARMA1 on Ser668, which in turn is essential for BCR mediated CARMA1-Bcl10-mucosal associated lymphoid tissue 1 ( MALT1 ) association and subsequent IKK activation
Kometani et al., J Exp Med 2011
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These mice had impaired T cell independent type II antibody responses in vivo and diminished IKK-ß activation and cellular responses to B cell receptor (BCR) cross linking in vitro