Parameswaran et al., J Biol Chem 2006
:
Taken together, these results suggest that p105 phosphorylation by GRK5 and binding of arrestin-2 negatively regulates LPS stimulated ERK activation
Yang et al., Mol Cell Biol 2012
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Activation of TPL-2/ERK signaling by IKK induced p105 proteolysis, therefore, induced a negative feedback loop to downregulate NF-?B dependent expression of the proinflammatory cytokine interleukin-12 (IL-12)