◀ Back to TP53

TP53 — VEGFA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: VEGFA → TP53 (decreases, VEGFA Activity)
  Evidence: It is important to note that more than 50% of human cancers contain mutations in p53, and that these mutations can affect the angiogenic balance. Kerbel and colleagues recently reported that cancer cells with p53 mutations are selected for their ability to survive under hypoxic conditions65. As well as their increased resistance to apoptosis, cells with p53 defects have been shown to downregulate the expression of TSP1 and upregulate the expression of VEGFA74.

Text-mined interactions from Literome

Ravi et al., Genes Dev 2000 (Adenocarcinoma...) : Loss of p53 in tumor cells enhances HIF-1alpha levels and augments HIF-1 dependent transcriptional activation of the vascular endothelial growth factor ( VEGF ) gene in response to hypoxia
Kondo et al., Cancer 2000 (Adenoma...) : The results of the current study demonstrated that angiogenesis develops in association with tumor progression from adenoma to noninvasive colorectal carcinoma, at least in part due to VEGF, and suggested that VEGF in m carcinomas is induced by mutant p53 , although alternative mechanisms of VEGF up-regulation may exist in sm carcinomas
Giatromanolaki et al., Oncol Res 2000 (Adenocarcinoma...) : Nuclear p53 accumulation was also related to a high MVD ( P = 0.004 ), and this was independent of VEGF or TP expression
Pal et al., Cancer Res 2001 (Breast Neoplasms) : Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor ( VPF/VEGF ) expression in mammary carcinoma ... p53 significantly inhibited the transcription of VPF/VEGF involving the transcription factor Sp1 ... It has been shown that p53 makes a complex with Sp1 and inhibits its binding to the VPF/VEGF promoter to prevent the transcriptional activation ... The present study indicates that p53 can also inhibit the hypoxic induction of Src kinase activity and thereby may prevent VPF/VEGF transcription
Pollmann et al., Cancer Res 2001 : Overexpression of the tumor suppressor p53 reduces VEGF production in HeLa cells
Tai et al., Blood 2002 (Multiple Myeloma...) : CD40 activation induces p53 dependent vascular endothelial growth factor secretion in human multiple myeloma cells ... Finally, adenovirus mediated wild-type p53 overexpression down-regulated CD40 induced VEGF expression and transmigration in MM cells expressing mutant p53
Yuan et al., J Clin Oncol 2002 (Carcinoma, Non-Small-Cell Lung...) : This result indicates that aberrant p53 expression may play a significant role in regulation of VEGF and IL-8 expression and be involved in controlling angiogenesis and explains the adverse prognosis of cancers with high aberrant p53 expression
Senoo et al., Oncogene 2002 : Tumor suppressor p53 has been shown to repress expression of vascular endothelial growth factor ( VEGF ), an endothelial cell-specific mitogen and a key mediator of tumor angiogenesis
Kern et al., Int J Oncol 2002 (Colorectal Neoplasms...) : In vitro studies have shown that these genetic alterations cause a loss of wild-type p53 induced anti-angiogenetic control and could possibly induce expression of the neoangiogenic vascular endothelial growth factor ( VEGF )
Fujisawa et al., Exp Mol Pathol 2003 (Carcinoma...) : It has been reported that tumor suppressor gene p53 regulates vascular endothelial growth factor ( VEGF ) expression, but the relation between them in endometrial carcinoma remains unclear
Theurillat et al., Pathol Res Pract 2003 (Bone Neoplasms...) : Analyzing the expression of genes known to be involved in the pathogenesis of vascular tumors, we found that the appearance of less differentiated tumor was paralleled by an accumulation of TP53 and murine double minute-2 (MDM-2) protein, decreased caveolin-1 (CAV-1) expression, and increased vascular endothelial growth factor ( VEGF ) expression
Narendran et al., Exp Hematol 2003 (Precursor B-Cell Lymphoblastic Leukemia-Lymphoma...) : Mutant p53 in bone marrow stromal cells increases VEGF expression and supports leukemia cell growth
Fujisawa et al., Hum Cell 2003 (Endometrial Neoplasms) : VEGF expression was down-regulated by p53 in endometrial carcinoma cells
Shellman et al., J Invest Dermatol 2003 (Melanoma...) : In addition, activated Ras and dominant negative p53 enhances the hypoxia induced VEGF protein release
Liang et al., J Steroid Biochem Mol Biol 2005 (Breast Neoplasms...) : p53 dependent inhibition of progestin induced VEGF expression in human breast cancer cells ... Progestin dependent VEGF induction was completely inhibited by PRIMA-1 activated p53 in all cell-types, but progestin dependent transcription of a progesterone regulated minimal promoter was only partially inhibited ... Progestin dependent induction of VEGF was also inhibited by stable transfection of wild-type p53 in T47-D cells
Menendez et al., Proc Natl Acad Sci U S A 2006 (Disease Progression...) : Although a precise mechanism has not been established, studies suggest that VEGF expression is negatively regulated by p53 , a master regulator and tumor suppressor
Ko et al., FEBS Lett 2006 : We investigated the role of p53 in nuclear factor (NF)-kappaB dependent, platelet activating factor (PAF) induced vascular endothelial growth factor ( VEGF ) expression
Qin et al., Proc Natl Acad Sci U S A 2006 : Cell cycle regulator E2F1 modulates angiogenesis via p53 dependent transcriptional control of VEGF ... These data disclose an unexpected function of endogenous E2F1 : regulation of angiogenic activity via p53 dependent transcriptional control of VEGF expression
Amine et al., Radiat Res 2006 (Neovascularization, Pathologic...) : Cidofovir administered with radiation displays an antiangiogenic effect mediated by E6 inhibition and subsequent TP53 dependent VEGF repression in HPV18+ cell lines
Jin et al., Eur J Histochem 2007 (Adenocarcinoma...) : The results indicate that cancer cell clones are already present at the adenoma stages showing positivity to DNA instability testing, enhanced proliferative activity, p53 mutation and induction of DFF45 and VEGF , at a time when the degree of morphological atypia are not yet large enough for them to be identified as cancer
Yang et al., Mol Cell Biol 2009 : Here, we show that induction of p53 by the small-molecule RITA ( reactivation of p53 and induction of tumor cell apoptosis ) [ 2,5-bis ( 5-hydroxymethyl-2-thienyl ) furan ] ( NSC-652287 ) inhibits HIF-1alpha and vascular endothelial growth factor expression in vivo and induces significant tumor cell apoptosis in normoxia and hypoxia in p53 positive cells
Nardinocchi et al., PloS one 2009 : Zinc supplementation to hypoxia treated cells increased HIPK2 protein stability and nuclear accumulation, leading to restoration of HIPK2 binding to HIF-1alpha promoter, repression of MDR1, Bcl2, and VEGF genes, and activation of the p53 apoptotic response to drug
Yoshioka et al., J Surg Res 2012 (Neovascularization, Pathologic...) : p53 inhibits vascular endothelial growth factor expression in solid tumor ... Here, we showed that expression of wild-type p53, but not null or mutated p53 , significantly suppressed HIF-1 activity and production of VEGF , which mostly depends on the HIF-1ß protein level
Kim et al., Cell Physiol Biochem 2011 : In this study, we attempted to characterize the mechanism by which p53 activity negatively regulates PAF induced VEGF expression
Ahmed et al., Cell death & disease 2011 (Anoxia...) : We have recently shown that induction of the p53 tumour suppressor protein by the small-molecule RITA ( reactivation of p53 and induction of tumour cell apoptosis ; 2,5-bis ( 5-hydroxymethyl-2-thienyl ) furan ) inhibits hypoxia-inducible factor-1a and vascular endothelial growth factor expression in vivo and induces p53 dependent tumour cell apoptosis in normoxia and hypoxia
Park et al., Mol Carcinog 2012 (Colonic Neoplasms...) : HFD feeding increased tumor tissue levels of Ki67, cyclin A, cyclin D1, CDK2, Bcl-xL, and Bcl-2 ; reduced p53 levels and TUNEL positive apoptotic cells ; increased the levels of CD45, CD68, CD31, VEGF , P-VEGF receptor-2, iNOS, and COX-2 as well as hemoglobin content ; and increased the levels of HIF-1a, P-STAT3-Y705, P-STAT3-S727, P-I?B-a, P-p65, p65, P-c-Jun, P-Akt, P-ERK1/2, P-p38, and P-SAPK/JNK
Farhang Ghahremani et al., Cell Death Differ 2013 (Anoxia...) : p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway ... Unexpectedly, and for the first time, we demonstrate that p53 rapidly induces VEGF transcription upon hypoxia exposure by binding, in an HIF-1a dependent manner, to a highly conserved and functional p53 binding site within the VEGF promoter
Kieser et al., Oncogene 1994 : Mutant p53 specifically increases TPA induction of VEGF without affecting the expression of other TPA inducible genes ... TPA dependent VEGF expression is also enhanced by human p53 mutated at amino acid 175
Mukhopadhyay et al., Cancer Res 1995 (Neovascularization, Pathologic) : Here we have studied the role of p53 , a tumor suppressor, and v-Src, an oncogene on VEGF regulation ... Wild-type p53 down-regulated endogenous VEGF mRNA level, as well as VEGF promoter activity, in a dose dependent manner, whereas mutant forms of p53 had no effect
Agani et al., Cancer Res 1997 (Carcinoma, Hepatocellular...) : p53 does not repress hypoxia induced transcription of the vascular endothelial growth factor gene
Ambs et al., Br J Cancer 1998 (Carcinoma, Small Cell...) : In summary, our data do not show a direct regulation of VEGF by p53 in NSCLC