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BMP2 — PTHLH
Text-mined interactions from Literome
Ito et al., Biochim Biophys Acta 1999
:
Furthermore, even in the
presence of
PTHrP ( 1-141 ),
BMP-6 increased the transcript level of type X collagen in a dose dependent manner
Pateder et al., J Cell Physiol 2001
:
While TGF-beta stimulated the expression of PTHrP ( 5-fold ), PTHrP caused a slight inhibition, and
BMP-2 markedly
inhibited PTHrP mRNA expression ... The
effect of TGF-beta,
BMP-2 , and PTHrP on the
PTHrP-promoter paralleled their effects on mRNA expression, with TGF-beta significantly increasing CAT activity, BMP-2 decreasing CAT activity, and PTHrP having a minimal effect
Farquharson et al., Endocrinology 2001
:
Expression of
bone morphogenetic protein-2 and 4 -- 7 was detected within the growth plate, and
PTHrP inhibited the expression of bone morphogenetic protein-4 and 6
Chan et al., Endocrinology 2003
:
These cells express the type 1 PTH/PTHrP receptor, thereby allowing
PTHrP to
inhibit bone morphogenetic protein 2 (BMP2) from enhancing gene expression of peroxisome proliferator activated receptor gamma and the adipocyte-specific protein aP2 and from augmenting the accumulation of lipid ... In the presence of
BMP2 ,
PTHrP or a protein kinase C ( PKC ) stimulator ( phorbol ester )
increased the expression of indexes of the osteoblast phenotype, including alkaline phosphatase, type I collagen, and osteocalcin, whereas a PKC inhibitor ( chelerythrin chloride ) inhibited PTHrP action ...
PTHrP and a phorbol ester increased gene expression of the BMP IA receptor, and both enhanced
BMP2 dependent
increases in promoter activity of the signaling molecule SMAD6
Yao et al., Arch Oral Biol 2007
:
Concurrently, the
upregulation of
BMP-2 by
PTHrP may stimulate bone growth at the base of the bony crypt to promote eruption
Hens et al., Development 2007
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PTHrP upregulates
BMP receptor 1A expression in the mammary mesenchyme, enabling it to respond to BMP4, which is expressed within mesenchymal cells underlying the ventral epidermis during mammary bud formation
Susperregui et al., J Cell Physiol 2008
:
BMP-2 regulation of
PTHrP and osteoclastogenic factors during osteoblast differentiation of C2C12 cells ... Here, we report that
BMP-2 rapidly
down-regulated PTHrP gene expression through a transcriptional mechanism in pluripotent mesenchymal C2C12 cells, whereas BMP-2 increased expression of PTHrP receptor
Terkeltaub et al., J Bone Miner Res 1998
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In contrast, basic fibroblast growth factor (bFGF), an inhibitor of chondrocyte maturation to hypertrophy, induced PTHrP in MCT cells and antagonized the
effects of BMP-2,
BMP-4 , BMP-6, and BMP-7 and TGF-beta on
PTHrP expression