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ADAM17 — EPHB2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Soond et al., J Cell Sci 2005
:
ERK mediated phosphorylation of Thr735 in
TNFalpha converting enzyme and its potential role in TACE protein trafficking
Küper et al., Am J Physiol Cell Physiol 2007
:
Conversely,
TACE inhibition
prevented TGF-alpha release ; EGFR, p38, and
ERK1/2 activation ; and COX-2 expression
Boots et al., J Biol Chem 2009
:
Both
ADAM17 activation and IL-8 release were
suppressed by inhibitors of
EGFR/ERK1/2 signaling, which can regulate ADAM17 activity by serine/threonine phosphorylation
Yamashita et al., Journal of ovarian research 2009
:
Activation of PKA, p38 MAPK and
ERK1/2 by gonadotropins in cumulus cells is
critical for induction of EGF-like factor and
TACE/ADAM17 gene expression during in vitro maturation of porcine COCs ... The results showed that PKA, p38 MAPK and
ERK1/2 positively
controlled the expression of EGF-like factor and
TACE/ADMA17 , the latter of which impacts the cumulus expansion and oocyte maturation of porcine COCs via the EGFR-ERK1/2 pathway in cumulus cells
Bell et al., Am J Med Sci 2010
(Fibrosis...) :
ADAM-17 is
activated by the mitogenic protein kinase
ERK in a model of kidney fibrosis
Dey et al., J Pharmacol Exp Ther 2010
:
EGFR transactivation is mediated by a disintegrin and metalloenzyme ( ADAM ) family members, which are required for both extracellular signal regulated kinase ( ERK ) and EGFR activation by BK. Using a gene silencing approach we observed that both BK-induced
ERK activation and BK-induced permeability decrease in podocytes is
attenuated by
ADAM17 down-regulation, and we identified epiregulin (ER) as the EGFR ligand participating in ADAM dependent BK2R-EGFR cross-talk
Kommaddi et al., FASEB J 2011
:
We show that Trk induced
ADAM17 phosphorylation and generation of the p75NTR ( ICD ) is
required for neurotrophin induced
Erk and Akt activation and for neurotrophin dependent survival signaling