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Text-mined interactions from Literome

Diez-Marques et al., Biochim Biophys Acta 2002 (Glomerulosclerosis, Focal Segmental) : Untreated and TGF-beta treated endoglin ( + ) cells showed significantly lower levels of collagens than those in control cells, indicating that endoglin negatively regulates ECM levels of collagens
Finnson et al., Osteoarthritis Cartilage 2010 (Osteoarthritis) : Our objective was to determine whether endoglin regulates TGF-ß/Smad signalling and extracellular matrix ( ECM ) production in human chondrocytes and whether its expression varies with chondrocyte differentiation state ... Endoglin enhances TGF-ß1 induced Smad1/5 phosphorylation and inhibits TGF-ß1 induced Smad2 phosphorylation, Smad3-driven transcriptional activity and ECM production in human chondrocytes ... Together, our results suggest that endoglin regulates the balance between TGF-ß/ALK1/Smad1/5 and ALK5/Smad2/3 signalling and ECM production in human chondrocytes and that endoglin may represent a marker for chondrocyte phenotype