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IKBKAP — NFKB1
Text-mined interactions from Literome
Jue et al., J Korean Med Sci 1999
(Arthritis, Rheumatoid) :
Aspirin and sodium salicylate
inhibit activation of
NF-KB by blocking
IkappaB kinase , a key enzyme in NF-kappaB activation
Hehner et al., J Immunol 1999
:
The antiinflammatory sesquiterpene lactone parthenolide
inhibits NF-kappa B by targeting the
I kappa B kinase complex
Zamanian-Daryoush et al., Mol Cell Biol 2000
:
NF-kappaB activation by double-stranded-RNA activated protein kinase ( PKR ) is mediated through
NF-kappaB inducing kinase and
IkappaB kinase
Gil et al., Oncogene 2000
:
Activation of
NF-kappa B by the dsRNA dependent protein kinase, PKR
involves the
I kappa B kinase complex
Matsushima et al., J Exp Med 2001
:
Both
nuclear factor (NF)-kappaB inducing kinase ( NIK ) and
inhibitor of kappaB (IkappaB) kinase ( IKK ) have been implicated as essential components for NF-kappaB activation in response to many external stimuli
Donepudi et al., J Immunol 2001
(Mast-Cell Sarcoma) :
Moreover, exposure of P815 tumor cells to a cell-permeable peptide that selectively
inhibits NF-kappaB activation by blocking the activation of the
IkappaB-kinase complex was found to inhibit the L-PAM induced B7-1 mRNA accumulation, indicating that NF-kappaB activation is essential for the L-PAM induced B7-1 gene expression
Zingarelli et al., FASEB J 2002
(Myocardial Infarction...) :
These events were preceded by degradation of inhibitor kappaBalpha ( IkappaBalpha ), activation of
IkappaB kinase complex (IKK) and c-Jun-NH2-terminal kinase (JNK), and subsequently
activation of
nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) as early as 15 min after reperfusion
Wong et al., Shock 2002
(Hyperoxia...) :
Hyperoxia prolongs tumor necrosis factor-alpha mediated
activation of
NF-kappaB : role of
IkappaB kinase
Anest et al., Nature 2003
:
NF-kappaB is a principal transcriptional regulator of diverse cytokine mediated processes and is tightly
controlled by the
IkappaB kinase complex ( IKK-alpha/beta/gamma )
Park et al., J Biol Chem 2003
:
Heat shock protein 27 association with the
I kappa B kinase complex regulates tumor necrosis factor alpha induced
NF-kappa B activation
Channavajhala et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
This inhibition is specific to Cot, because Ras induced ERK and
IkappaB kinase induced
NF-kappaB activation are not significantly affected by hKSR-2 co-expression
Prajapati et al., J Biol Chem 2004
:
Protein phosphatase 2Cbeta association with the
IkappaB kinase complex is
involved in regulating
NF-kappaB activity
Eickhoff et al., J Biol Chem 2004
(Cytomegalovirus Infections) :
A stable inhibitor of NF-kappaB ( IkappaB ) reverses the RICK inhibitory effect, and
activation of
NF-kappaB by
IkappaB kinase beta expression is inhibitory to HCMV, demonstrating that NF-kappaB activation is part of a potent anti-HCMV response
Huang et al., J Biol Chem 2004
:
Activation of
NFkappaB requires the activity of
IkappaB kinase , a kinase complex that contains two catalytic subunits, IKKalpha and IKKbeta, and a non-enzymatic regulatory subunit, IKKgamma
Watanabe et al., Proc Natl Acad Sci U S A 2004
(MAP Kinase Signaling System) :
The NF-kappaB translocation dependent pathway involves
NF-kappaB inducing
kinase-IkappaB kinase beta/gamma dependent phosphorylation and degradation of IkappaBalpha, whereas the NF-kappaB translocation independent pathway involves mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase kinase kinase 1-dependent activation of MAPK kinase 3/6-p38 MAPK pathway
Lamkanfi et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
We demonstrate that caspase-1 interacts with RIP2 and that dominant negative forms of RIP2 and
IkappaB kinase complex-beta inhibit caspase-1 mediated
NF-kappaB activation
Khoshnan et al., J Neurosci 2004
(Nerve Degeneration) :
In inducible PC12 cells and in HD transgenic mice, mutant Htt activates the
IkappaB kinase complex (IKK) , a key
regulator of
NF-kappaB
Chan et al., Biochem Biophys Res Commun 2005
:
Tpl2/COT1 was shown to participate in CD40 signaling based on the ability of a catalytically inactive mutant to suppress CD40 mediated
IkappaB kinase activation and
induction of
NFkappaB-responsive promoters, without affecting signaling by TNF
Mortaz et al., Biochem Pharmacol 2005
:
We thus propose that the anti-inflammatory effects of ASA in mast cells are due to suppression of
IkappaB kinase activity, thereby
inhibiting subsequent phosphorylation and degradation of IkappaB-alpha, activation of
NF-kappaB , and transcription of proinflammatory cytokines
Aggarwal et al., Mol Pharmacol 2006
(Neoplasm Metastasis) :
Curcumin also suppressed
NF-kappaB reporter activity
induced by tumor necrosis factor receptor (TNFR)1, TNFR2, NF-kappaB inducing kinase,
IkappaB kinase complex (IKK) , and the p65 subunit of NF-kappaB
Song et al., Proc Natl Acad Sci U S A 2006
:
Because IRAK1 is upstream of TRAF6 in IL-1 activation of NF-kappaB, the potential role of IRAK1 in LMP1 mediated
NF-kappaB activation through TRAF6 and
inhibitor of kappaB (IkappaB) kinase ( IKK ) was initially investigated
Adli et al., J Biol Chem 2006
(Inflammation) :
NF-kappaB activation downstream of lipopolysaccharide or cytokine stimulation is
controlled by the
IkappaB kinase complex , which contains IKKalpha and IKKbeta
Gilmore et al., Oncogene 2006
:
NF-kappaB signaling is primarily
regulated by inhibitor kappaB ( IkappaB ) proteins and the
IkappaB kinase complex through two major pathways : the canonical and non-canonical NF-kappaB pathways
Zhang et al., PloS one 2006
:
Both phenotypes are rescued by injection of RNA encoding the anti-apoptotic protein Bcl-xL ; Bcl-xL 's effects are dependent upon
IkappaB kinase mediated activation of the bipartite transcription factor
NF-kappaB
Tudhope et al., J Immunol 2007
:
The role of
IkappaB kinase 2, but not
activation of
NF-kappaB , in the release of CXCR3 ligands from IFN-gamma stimulated human bronchial epithelial cells
Shultz et al., J Interferon Cytokine Res 2007
:
Activation of
NF-kappaB requires the
inhibitor of kappaB (IkappaB) kinase ( IKK) complex, which is made up of two functional kinases, IKKalpha and IKKbeta, and the scaffolding protein IKKgamma
Teruya et al., BMC microbiology 2007
:
Collectively, these results suggest that L. pneumophila induces activation of NF-kappaB through an intracellular signaling pathway that involves
NF-kappaB inducing kinase and
IkappaB kinase , leading to IL-8 gene transcription, and that hsp90 acts as a crucial regulator in L. pneumophila induced IL-8 expression, presumably contributing to immune response in L. pneumophila
Kim et al., Mol Pharmacol 2008
(Inflammation...) :
Here, we demonstrate that the novel small-molecule benzoxathiole 6,6-dimethyl-2- ( phenylimino ) -6,7-dihydro-5H-benzo- [ 1,3 ] oxathiol-4-one ( BOT-64 )
inhibits NF-kappaB activation with an IC ( 50 ) value of 1 muM by blocking
inhibitory kappaB(IkappaB) kinase beta ( IKKbeta ), and suppresses NF-kappaB regulated expression of inflammatory genes in lipopolysaccharide (LPS) activated RAW 264.7 macrophages
Boersma et al., Science signaling 2008
:
Transcriptional
activation by
NF-kappaB and chromatin remodeling by inhibitor of kappaB
(IkappaB) kinase complex ( IKK ) have been linked to recall and reconsolidation of conditioned fear memories in the mammalian central nervous system
Ragheb et al., Biochem Biophys Res Commun 2008
(Disease Models, Animal...) :
Interestingly,
IkappaB-kinase beta (IKKbeta)
dependent NF-kappaB was activated in hepatocytes from the fructose fed hamster as an indication for PKC activation
Hagemann et al., J Exp Med 2008
(Neoplasms) :
We show that macrophages are polarized via interleukin (IL)-1R and MyD88 to an immunosuppressive `` alternative '' phenotype that requires
IkappaB kinase beta
mediated NF-kappaB activation
Kim et al., Mol Cancer Res 2008
(Glioma) :
Here, we report that the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ) blocks MMP-9 secretion and that HA-induced
nuclear factor-kappaB (NF-kappaB) activation is
mediated by
IkappaB kinase , which phosphorylates the NF-kappaB inhibitor IkappaBalpha and promotes its degradation
Fan et al., J Biol Chem 2009
(MAP Kinase Signaling System...) :
The ability of Src to enhance SF stimulation of NF-kappaB activity was due, in part, to its ability to stimulate Akt and
IkappaB kinase activity ; and Src mediated stimulation of
NF-kappaB was
due , in part, to a Rac1/MKK3/6/p38 pathway and was Akt dependent
Tanabe et al., Journal of neuroinflammation 2010
(Glioma) :
Wedelolactone, an inhibitor of
IkappaB kinase ,
suppressed both TNF-alpha induced IkappaB phosphorylation and
NFkappaB phosphorylation at Ser 536 and Ser 468
Uhlik et al., J Biol Chem 1998
:
NF-kappaB inducing kinase and
IkappaB kinase participate in human T-cell leukemia virus I Tax mediated NF-kappaB activation