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RSPO1 — WNT16
Text-mined interactions from Literome
Kazanskaya et al., Dev Cell 2004
:
R-Spondin2 is a secreted
activator of
Wnt/beta-catenin signaling and is required for Xenopus myogenesis
Binnerts et al., Proc Natl Acad Sci U S A 2007
:
R-Spondin1 regulates
Wnt signaling by inhibiting internalization of LRP6 ... We show that
RSpo1 activity critically
depends on the presence of canonical
Wnt ligands and LRP6
Tamashiro et al., Biochim Biophys Acta 2008
:
By contrast, female sex determination depends on the action of
Rspo1 and Wnt4, the
regulators of
Wnt/beta-catenin signaling
Lu et al., Biochemistry 2010
:
Mesd not only blocks binding of Wnt antagonists Dkk1 and Sclerostin to LRP5 and LRP6 but also inhibits Wnt3A and
Rspondin1 induced
Wnt/beta-catenin signaling in LRP5- and LRP6 expressing cells
Krönke et al., Arthritis Rheum 2010
(Arthritis, Experimental...) :
Moreover, we determined the
effect of
Rspo1 on
Wnt signaling activity and osteoprotegerin (OPG) expression in murine primary osteoblasts
Gore et al., Development 2011
(Neovascularization, Pathologic...) :
A mutation in
R-spondin1 (rspo1) , a
Wnt signaling
regulator , was uncovered during a forward-genetic screen for angiogenesis-deficient mutants in the zebrafish
Hao et al., Nature 2012
(Colorectal Neoplasms...) :
These data suggest that
R-spondin enhances
Wnt signalling by inhibiting ZNRF3
Jin et al., Int J Biochem Cell Biol 2012
(Bone Diseases...) :
Recent advances in the RSPO research field revealed some of the in vivo functions of RSPOs and provided new information regarding the mechanistic
roles of
RSPO activity in regulation of
WNT signaling