◀ Back to NFKB1

HLA-DRB1 — NFKB1

Text-mined interactions from Literome

Gibson et al., Mol Cell Biol 2000 : Inhibition of NF-kappaB activation by expression of kinase-inactive MEK kinase 1 ( MEKK1 ) or dominant negative IkappaB ( DeltaIkappaB ) blocked the increase in DR4 and DR5 expression following etoposide treatment
Kim et al., Biochem Biophys Res Commun 2002 : In addition, we previously found that cross linking of MHC class II molecules using anti-MHC class II antibodies inhibited NF-kappaB activation in resting B cells isolated from mouse spleen
Shetty et al., Apoptosis 2002 : Tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) up-regulates death receptor 5 (DR5) mediated by NFkappaB activation in epithelial derived cell lines
Chen et al., Cancer Res 2003 (Breast Neoplasms) : Overexpression of a transdominant negative mutant of the inhibitory protein I kappa B alpha results in down-regulation of constitutively active NF-kappa B , induction of DR5 , and tumor necrosis factor receptor (TNFR) 1-associated death domain expression and enhancement of TRAIL sensitivity
Singh et al., Oncogene 2005 (Breast Neoplasms) : HDAC inhibitors synergized with TRAIL by inducing DRs DR4/TRAIL-R1 and DR5/TRAIL-R2 through NFkappaB activation and some of the proapoptotic members of the Bcl-2 family, and engaging the mitochondrial pathway
Shetty et al., Mol Cell Biol 2005 (Breast Neoplasms) : The mechanism of NF-kappaB induced DR5 expression is, however, unknown ... This provides a mechanism for regulating NF-kappaB mediated DR5 expression and could explain the differential roles NF-kappaB plays in regulating apoptosis
Graham et al., Cell cycle (Georgetown, Tex.) 2005 : NFkappaB activation induces death receptor 5 (DR5) expression following DNA damaging agent etoposide treatment but not following growth factor EGF treatment
Kumari et al., Biochem Biophys Res Commun 2005 (Neoplasms, Experimental) : The enhanced NFkappaB activity resulted in the elevation of TRAIL and its receptor DR4 , both known to induce apoptosis
Wosik et al., J Neurol Sci 2007 : TNFR1 ligation induces NFkappaB activation and the upregulation of chemokines MCP-1 and IL-8, as well as adhesion molecules ICAM-1 and VCAM-1, while Fas and DR5 triggering activate the extracellular signal regulated kinases-1 and -2 ( Erk 1/2, p42/44 MAPK ) inducing the release of matrix metalloproteinase 9 (MMP9) by BBB derived ECs
Shankar et al., Molecular cancer 2008 (Neoplasm Metastasis...) : In xenogrfated tumors, curcumin upregulated the expression of TRAIL-R1/DR4, TRAIL-R2/DR5 , Bax, Bak, p21/WAF1, and p27/KIP1, and inhibited the activation of NFkappaB and its gene products such as cyclin D1, VEGF, uPA, MMP-2, MMP-9, Bcl-2 and Bcl-XL
Mendoza et al., Apoptosis 2008 : Death receptor-4 (DR4) expression is regulated by transcription factor NF-kappaB in response to etoposide treatment ... Herein, we determined that transcription factor NF-kappaB plays a role in genotoxin induced DR4 expression ... Moreover, expression of the p65 subunit of NF-kappaB is sufficient to increase DR4 protein levels ... Taken together, NF-kappaB plays a role in up-regulation of DR4 following etoposide treatment
Chen et al., J Immunol 2008 : Both p53 small interfering RNA and NF-kappaB inhibitor suppressed DR5 expression, strengthening the significance of p53 and NF-kappaB in DR5 transcription
Trede et al., J Immunol 1993 (Leukemia, Monocytic, Acute) : Induction of both NF-kappa B DNA binding proteins and NF-kappa B enhancer function was down-regulated by inhibitors of protein kinase C and protein tyrosine kinase, indicating a role for these protein kinases in the induction of NF-kappa B by MHC class II ligands
Grammer et al., J Immunol 1998 (Burkitt Lymphoma) : By contrast, induction of apoptosis, activation of NF-kappaB , generation of granulocyte-macrophage CSF, and up-regulation of CD54, MHC class II , and CD95 were unaffected by the TRAF3 dominant negative