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PLAU — PTH

Text-mined interactions from Literome

Fukumoto et al., J Cell Physiol 1992 : In order to determine the mechanism by which parathyroid hormone (PTH) stimulates plasminogen activator (PA) activity in rat osteoblasts, we investigated the effect of human PTH ( 1-34 ) [ hPTH ( 1-34 ) ] on the synthesis of mRNAs for tissue-type PA (tPA), urokinase-type PA (uPA) , and PA inhibitor-1 (PAI-1), and on release of PA activity and PAI-1 protein in both normal rat calvarial osteoblasts and UMR 106-01 osteogenic sarcoma cells
Leloup et al., J Bone Miner Res 1991 (Bone Resorption) : However, PTH also enhanced the release of uPA ( both the 48 kD and the 29 kD forms ) from the bones into the media ... Although inhibiting bone resorption, calcitonin had no effect on the PTH induced accumulation of PA in bone or on the release of tPA, but it prevented the PTH induced accumulation of 29 kD uPA in the culture fluids