◀ Back to MAPK1

LIFR — MAPK1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK1 → LIFR (increases, LIFR Activity, MAPK1 Activity)
  Evidence: their expression is up-regulated by the activation of leukemia inhibitory factor receptor (LIF-R) and prostacyclin receptor (IP-R) via the extracellular signal-regulated kinase (ERK) pathway and cAMP production, respectively.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: LIFR — MAPK1 (in vivo) Schiemann et al., Proc Natl Acad Sci U S A 1995*

Text-mined interactions from Literome

Bartoe et al., J Neurochem 2000 : Coexpression of catalytically inactive, but not wild-type, SHP-2 reduced LIFR- and gp130 mediated activation of MAPK up to 75 %
Schiemann et al., J Biol Chem 1997 : Our results demonstrate that gp130 and LIFR stimulate MAPK activity through box 3-independent mechanisms involving : ( i ) effects at Tyr-118 and Tyr-115, respectively, for maximal stimulation of MAPK activity and ( ii ) a Jak/Tyk dependent pathway that, together with Tyr-118- or Tyr-115 generated signals, converges at the level of Ras during activation of MAPK by cytokine